HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: HECD1 (Q9ULT8)
E3 ubiquitin-protein ligase HECTD1 (EC 2.3.2.26) (E3 ligase for inhibin receptor) (EULIR) (HECT domain-containing protein 1)
Gene: HECTD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.80	0.675

Property	Details
Experiments	27182664, 17550899
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 2610
+	Hs
		475963 UBC_HUMAN (1-685): 0: 846: 100.00		HECW1_HUMAN (1637-2609): 3.58e-129: 450: 14.66
+	Hs
		304002 UBC_HUMAN (1-685): 0: 846: 100.00		UBR5_HUMAN (1985-2609): 1.07e-116: 418: 16.94
+	Hs
		476229 UBC_HUMAN (1-685): 0: 846: 100.00		NED4L_HUMAN (2255-2608): 4.26e-117: 399: 21.67
+	Hs
		476205 UBC_HUMAN (1-685): 0: 846: 100.00		ITCH_HUMAN (2234-2608): 3.18e-117: 398: 21.88
+	Hs
		476403 UBC_HUMAN (1-685): 0: 846: 100.00		SMUF2_HUMAN (2235-2607): 4.78e-118: 395: 20.62
+	Hs
		476414 UBC_HUMAN (1-685): 0: 846: 100.00		SMUF1_HUMAN (2220-2607): 1.5e-116: 391: 19.70
+	Hs
		125113 UBC_HUMAN (1-685): 0: 846: 100.00		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	Hs
		476350 UBC_HUMAN (1-685): 0: 846: 100.00		WWP1_HUMAN (2328-2608): 5.47e-91: 321: 29.27
+	Dm
		89879 UBIQP_DROME (1-610): 0: 752: 99.84		D5SHR3_DROME (2200-2609): 4.37e-116: 378: 19.21
+	Hs
		475762 UBC_HUMAN (1-685): 0: 846: 100.00		TRIPC_HUMAN (5-1083): 4.48e-58: 225: 14.03
+	Hs
		475652 UBC_HUMAN (1-685): 0: 846: 100.00		UBE3A_HUMAN (2406-2607): 5.17e-25: 116: 34.95
+	Hs
		475799 UBC_HUMAN (1-685): 0: 846: 100.00		UBE3C_HUMAN (2405-2610): 9.09e-23: 109: 32.37
+	Dm
		1376481 Q9W418_DROME (229-685): 0: 557: 99.78		Q9W325_DROME (2190-2609): 1.1e-117: 382: 19.23
+	Sc
		477197 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UFD4_YEAST (2031-2610): 2.7e-129: 448: 28.16
+	Sc
		477380 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		HUL5_YEAST (2050-2610): 8.38e-117: 397: 18.66
+	Sc
		477293 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		RSP5_YEAST (2265-2608): 2.06e-105: 360: 20.86
+	Ce
		477557 UBIQ1_CAEEL (1-229): 5.97e-87: 292: 98.25		Q9GUP2_CAEEL (2359-2608): 2.04e-79: 297: 29.57
+	Hs
		125347 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		WWP2_HUMAN (2265-2608): 1.64e-107: 368: 24.86
+	At
		1091762 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UPL2_ARATH (2424-2604): 7.84e-20: 100: 34.60
+	At
		1091758 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UPL1_ARATH (2424-2604): 1.56e-19: 99.4: 34.60