HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: FAF1 (Q9UNN5)
FAS-associated factor 1 (hFAF1) (UBX domain-containing protein 12) (UBX domain-containing protein 3A)
Gene: FAF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.979

Property	Details
Experiments	34642328, 38803224, 22876279, 19722279, 23293021, 23314748, 18775313, 30935967, 35920641, 15743842, 24885147
Identification Methods	pull down, affinity chromatography technology, unspecified method, biochemical, two hybrid
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	UBA_4~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 650
+	Hs
		299310 UBC_HUMAN (1-685): 0: 846: 100.00		UBXN7_HUMAN (278-649): 4.64e-77: 255: 15.79
+	Hs
		476174 UBC_HUMAN (1-685): 0: 846: 100.00		FAF2_HUMAN (320-649): 2.56e-68: 231: 22.29
+	Hs
		476327 UBC_HUMAN (1-685): 0: 846: 100.00		UBXN6_HUMAN (395-645): 7.43e-34: 136: 15.73
+	Hs
		475650 UBC_HUMAN (1-685): 0: 846: 100.00		UBXN1_HUMAN (414-649): 9.29e-34: 132: 16.00
+	Mm
		476721 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		FAF1_MOUSE (1-650): 0: 844: 96.31
+	Hs
		398140 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		FAF1_HUMAN (1-650): 0: 840: 100.00
+	Hs
		475246 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		FAF1_HUMAN (1-650): 0: 840: 100.00
+	Rn
		1144247 UBC_RAT (1-108): 1.27e-29: 127: 90.74		FAF1_RAT (1-650): 0: 816: 94.62
+	Sc
		477464 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBX5_YEAST (270-650): 6.39e-48: 177: 11.71
+	Sc
		477438 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBX2_YEAST (358-649): 2.56e-42: 163: 14.24
+	Mm
		476842 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBXN7_MOUSE (278-649): 3.31e-82: 269: 16.56
+	Hs
		299309 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		UBXN7_HUMAN (278-649): 4.64e-77: 255: 15.79
+	Mm
		476779 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		FAF2_MOUSE (320-649): 6.08e-68: 230: 22.29
+	Hs
		475128 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		FAF2_HUMAN (320-649): 2.56e-68: 231: 22.29
+	Mm
		476957 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBXN1_MOUSE (414-649): 9.77e-36: 138: 17.20
+	Hs
		398087 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		UBXN6_HUMAN (395-645): 7.43e-34: 136: 15.73
+	Hs
		397924 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		UBXN1_HUMAN (414-649): 9.29e-34: 132: 16.00
+	Mm
		476974 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBXN6_MOUSE (395-645): 8.42e-25: 109: 14.61