HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UB2D4 (Q9Y2X8)
Ubiquitin-conjugating enzyme E2 D4 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme D4) (HBUCE1) (Ubiquitin carrier protein D4) (Ubiquitin-protein ligase D4)
Gene: UBE2D4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	30884854, 27182664
Identification Methods	enzymatic study, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UQ_con~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0016567 - protein ubiquitination GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 147
+	Hs
		475501 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D1_HUMAN (1-147): 4.61e-83: 241: 91.84
+	Hs
		475586 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D2_HUMAN (1-147): 1.54e-82: 240: 93.20
+	Hs
		475550 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D3_HUMAN (1-147): 1.56e-81: 238: 91.84
+	Hs
		476218 UBC_HUMAN (1-685): 0: 846: 100.00		UB2E2_HUMAN (4-146): 3.5e-75: 224: 64.34
+	Hs
		476155 UBC_HUMAN (1-685): 0: 846: 100.00		UB2E3_HUMAN (4-146): 1.24e-74: 223: 64.34
+	Hs
		475504 UBC_HUMAN (1-685): 0: 846: 100.00		UB2E1_HUMAN (4-146): 4.67e-73: 218: 64.34
+	Hs
		475485 UBC_HUMAN (1-685): 0: 846: 100.00		UBE2A_HUMAN (2-144): 4.45e-71: 211: 41.26
+	Hs
		475597 UBC_HUMAN (1-685): 0: 846: 100.00		UBE2B_HUMAN (2-144): 2.02e-70: 210: 39.86
+	Hs
		475552 UBC_HUMAN (1-685): 0: 846: 100.00		UBE2N_HUMAN (4-147): 1.52e-69: 208: 46.53
+	Xl
		919927 Q7SY79_XENLA (77-685): 0: 744: 99.84		UB2D2_XENLA (1-147): 1.54e-82: 240: 93.20
+	Dm
		639414 Q9W418_DROME (229-685): 0: 557: 99.78		UBCD1_DROME (1-147): 4.66e-82: 239: 92.52
+	Sc
		477103 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBC4_YEAST (3-147): 9.94e-80: 233: 80.69
+	At
		1091932 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC28_ARATH (1-147): 8.06e-84: 244: 80.27
+	At
		715116 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC8_ARATH (1-147): 7.07e-83: 241: 80.27
+	At
		715132 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC9_ARATH (1-147): 1.26e-82: 241: 80.27
+	At
		715147 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC10_ARATH (1-147): 1.22e-82: 241: 79.59
+	At
		715157 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC11_ARATH (1-147): 8.34e-83: 241: 79.59
+	Sc
		477123 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBC1_YEAST (4-146): 8.4e-43: 142: 46.90
+	At
		790155 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC2_ARATH (2-144): 1.44e-70: 210: 46.85
+	At
		639385 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC1_ARATH (2-144): 2.65e-70: 209: 46.85