HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UBP15 (Q9Y4E8)
Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Unph-2) (Unph4)
Gene: USP15

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.984

Property	Details
Experiments	28190767, 29576527, 27182664, 33141564, 34642328, 36114200, 38803224, 25527291, 28088760, 27256865, 31952546, 16005295, 20622874, 19373254, 22626734, 24850914
Identification Methods	pull down, proximity labelling technology, affinity chromatography technology, enzymatic study
Interaction Type	direct interaction, physical association, deubiquitination reaction

Property	Details
Interacting Pfam domains	DUSP~ubiquitin, UCH~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 981
+	Hs
		475693 UBC_HUMAN (1-685): 0: 846: 100.00		UBP4_HUMAN (1-981): 0: 794: 55.38
+	Hs
		475502 UBC_HUMAN (1-685): 0: 846: 100.00		UBP11_HUMAN (9-946): 0: 661: 43.58
+	Hs
		301354 UBC_HUMAN (1-685): 0: 846: 100.00		UBP19_HUMAN (197-960): 5.82e-149: 477: 29.50
+	Hs
		475954 UBC_HUMAN (1-685): 0: 846: 100.00		UBP31_HUMAN (287-937): 1.96e-116: 390: 26.28
+	Hs
		476644 UBC_HUMAN (1-685): 0: 846: 100.00		UBP16_HUMAN (165-932): 1.1e-91: 311: 16.98
+	Hs
		475990 UBC_HUMAN (1-685): 0: 846: 100.00		UBP37_HUMAN (126-958): 3.63e-87: 302: 14.10
+	Hs
		475957 UBC_HUMAN (1-685): 0: 846: 100.00		UBP45_HUMAN (288-932): 2.23e-75: 266: 17.97
+	Hs
		476545 UBC_HUMAN (1-685): 0: 846: 100.00		UBP21_HUMAN (570-935): 1.17e-66: 236: 20.32
+	Hs
		271022 UBC_HUMAN (1-685): 0: 846: 100.00		UBP2_HUMAN (647-935): 1.13e-62: 226: 25.09
+	Hs
		475440 UBC_HUMAN (1-685): 0: 846: 100.00		UBP8_HUMAN (602-930): 8.61e-59: 221: 25.68
+	Hs
		476213 UBC_HUMAN (1-685): 0: 846: 100.00		UBP47_HUMAN (624-977): 2.99e-56: 214: 14.94
+	Hs
		476579 UBC_HUMAN (1-685): 0: 846: 100.00		UBP22_HUMAN (772-933): 1.82e-57: 208: 32.20
+	Hs
		476097 UBC_HUMAN (1-685): 0: 846: 100.00		UBP33_HUMAN (400-652): 3.18e-25: 115: 12.38
+	Hs
		475403 UBC_HUMAN (1-685): 0: 846: 100.00		UBP6_HUMAN (873-972): 2.37e-22: 106: 33.00
+	Hs
		476067 UBC_HUMAN (1-685): 0: 846: 100.00		UBP32_HUMAN (873-972): 4.15e-22: 105: 35.00
+	Hs
		476658 UBC_HUMAN (1-685): 0: 846: 100.00		UBP3_HUMAN (282-469): 1.11e-16: 86.3: 30.29
+	Dm
		477538 UBIQP_DROME (1-610): 0: 752: 99.84		NOT_DROME (281-468): 7.59e-16: 83.6: 28.27
+	Sc
		477284 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBP12_YEAST (9-954): 9.53e-142: 457: 24.65
+	Sc
		477294 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBP5_YEAST (764-932): 4.74e-53: 201: 29.73
+	Mm
		101489 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBP32_MOUSE (860-972): 1.15e-22: 107: 31.86