HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.978

Property	Details
Experiments	15125833, 15327770, 25494483, 27507811, 29176576, 29537486, 30355448, 36098982, 22033459, 23437331, 19820695, 17703191, 18239685
Identification Methods	enzymatic study, affinity chromatography technology, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	ubiquitin~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0010008 - endosome membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 522
+	Hs
		475684 UBC_HUMAN (1-685): 0: 846: 100.00		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		476299 UBC_HUMAN (1-685): 0: 846: 100.00		TRAF4_HUMAN (54-500): 6.36e-91: 287: 26.11
+	Hs
		129527 UBC_HUMAN (1-685): 0: 846: 100.00		TRAF5_HUMAN (43-500): 4.95e-87: 280: 25.23
+	Hs
		475691 UBC_HUMAN (1-685): 0: 846: 100.00		TRAF1_HUMAN (50-501): 5.58e-64: 216: 19.40
+	Hs
		475753 UBC_HUMAN (1-685): 0: 846: 100.00		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Hs
		475328 UBC_HUMAN (1-685): 0: 846: 100.00		RO52_HUMAN (64-403): 5.77e-45: 166: 14.97
+	Hs
		475297 UBC_HUMAN (1-685): 0: 846: 100.00		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		476635 UBC_HUMAN (1-685): 0: 846: 100.00		TRI17_HUMAN (58-408): 7.59e-43: 160: 11.86
+	Hs
		475680 UBC_HUMAN (1-685): 0: 846: 100.00		TRI26_HUMAN (61-410): 2.85e-38: 149: 14.59
+	Hs
		476330 UBC_HUMAN (1-685): 0: 846: 100.00		TRIM5_HUMAN (56-315): 8.46e-38: 147: 16.11
+	Hs
		475842 UBC_HUMAN (1-685): 0: 846: 100.00		RN151_HUMAN (54-204): 2.32e-33: 128: 28.03
+	Hs
		476632 UBC_HUMAN (1-685): 0: 846: 100.00		RN114_HUMAN (63-232): 4.73e-33: 127: 19.13
+	Hs
		476160 UBC_HUMAN (1-685): 0: 846: 100.00		RN166_HUMAN (61-222): 7.37e-16: 79.1: 22.94
+	Hs
		476188 UBC_HUMAN (1-685): 0: 846: 100.00		RN125_HUMAN (62-193): 1.59e-11: 66: 25.83
+	Xl
		1186351 Q7SY79_XENLA (77-685): 0: 744: 99.84		NF7B_XENLA (7-404): 2.74e-43: 164: 9.58
+	Hs
		924227 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Mm
		476671 UBB_MOUSE (457-685): 2.3e-86: 275: 99.56		RO52_MOUSE (51-403): 1.44e-45: 167: 14.17
+	Hs
		923989 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Hs
		301744 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		TRI37_HUMAN (56-501): 7.36e-43: 165: 13.89
+	Hs
		924151 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		TRI31_HUMAN (58-334): 3.02e-35: 138: 15.00