HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: RN115 (Q9Y4L5)
E3 ubiquitin-protein ligase RNF115 (EC 2.3.2.27) (RING finger protein 115) (RING-type E3 ubiquitin transferase RNF115) (Rab7-interacting RING finger protein) (Rabring 7) (Zinc finger protein 364)
Gene: RNF115

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.850

Property	Details
Experiments	31494268, 38803224, 18819927
Identification Methods	unspecified method, pull down, two hybrid, protein complementation assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ubiquitin~zf-RING_2
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 304
+	Hs
		476301 UBC_HUMAN (1-685): 0: 846: 100.00		RN126_HUMAN (17-282): 5.46e-59: 192: 44.37
+	Hs
		476073 UBC_HUMAN (1-685): 0: 846: 100.00		PJA1_HUMAN (79-275): 2.66e-29: 119: 18.91
+	Hs
		476007 UBC_HUMAN (1-685): 0: 846: 100.00		GOLI_HUMAN (58-298): 4.27e-29: 116: 15.95
+	Hs
		476347 UBC_HUMAN (1-685): 0: 846: 100.00		RNF38_HUMAN (85-271): 1.54e-28: 116: 23.40
+	Hs
		476491 UBC_HUMAN (1-685): 0: 846: 100.00		RN181_HUMAN (192-294): 1.74e-31: 116: 34.58
+	At
		1210477 UBQ10_ARATH (305-685): 2.63e-153: 453: 95.80		Q9FM98_ARATH (13-300): 3.36e-39: 143: 25.89
+	At
		1091813 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		RNG1L_ARATH (5-298): 2.4e-51: 173: 26.67
+	At
		1092053 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		Q9FM98_ARATH (13-300): 3.36e-39: 143: 25.89
+	At
		955780 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		ATL1_ARATH (123-302): 4.68e-28: 113: 22.75
+	Mm
		476994 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RN115_MOUSE (18-304): 6.43e-80: 246: 93.06
+	Hs
		398150 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		RN115_HUMAN (1-304): 2.11e-80: 247: 100.00
+	At
		477669 UBQ11_ARATH (533-685): 2.54e-59: 201: 95.43		Q9FM98_ARATH (13-300): 3.36e-39: 143: 25.89
+	Mm
		476947 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RN126_MOUSE (17-282): 2.66e-60: 196: 44.72
+	Hs
		475173 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		RN126_HUMAN (17-282): 5.46e-59: 192: 44.37
+	Hs
		924057 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		GOLI_HUMAN (58-298): 4.27e-29: 116: 15.95
+	Hs
		924199 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		RN181_HUMAN (192-294): 1.74e-31: 116: 34.58
+	Mm
		476987 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RN181_MOUSE (193-290): 1.21e-30: 115: 35.71
+	Hs
		475090 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		GOLI_HUMAN (58-298): 4.27e-29: 116: 15.95
+	Hs
		475216 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		RN181_HUMAN (192-294): 1.74e-31: 116: 34.58