HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: ARI1 (Q9Y4X5)
E3 ubiquitin-protein ligase ARIH1 (EC 2.3.2.31) (H7-AP2) (HHARI) (Monocyte protein 6) (MOP-6) (Protein ariadne-1 homolog) (ARI-1) (UbcH7-binding protein) (UbcM4-interacting protein) (Ubiquitin-conjugating enzyme E2-binding protein 1)
Gene: ARIH1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.862

Property	Details
Experiments	28552575, 27312108, 38803224
Identification Methods	pull down, x-ray crystallography
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	Ariadne~ubiquitin, IBR~ubiquitin, ubiquitin~zf-C3HC4
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 557
+	Hs
		312458 UBC_HUMAN (1-685): 0: 846: 100.00		ARI2_HUMAN (53-545): 6.02e-149: 438: 31.26
+	Hs
		476496 UBC_HUMAN (1-685): 0: 846: 100.00		AKIB1_HUMAN (96-548): 1.82e-125: 396: 26.05
+	Hs
		475939 UBC_HUMAN (1-685): 0: 846: 100.00		RN19B_HUMAN (170-396): 9.81e-68: 234: 25.82
+	Hs
		476460 UBC_HUMAN (1-685): 0: 846: 100.00		RN216_HUMAN (90-401): 4.09e-66: 232: 15.57
+	Hs
		476187 UBC_HUMAN (1-685): 0: 846: 100.00		RNF31_HUMAN (127-397): 1.98e-58: 212: 19.22
+	Hs
		475976 UBC_HUMAN (1-685): 0: 846: 100.00		R144B_HUMAN (159-382): 6.89e-58: 197: 25.97
+	Hs
		226335 UBC_HUMAN (1-685): 0: 846: 100.00		PRKN_HUMAN (151-388): 3.75e-55: 194: 22.10
+	Hs
		475494 UBC_HUMAN (1-685): 0: 846: 100.00		R144A_HUMAN (184-376): 7.21e-52: 181: 30.69
+	Dm
		477528 UBIQP_DROME (1-610): 0: 752: 99.84		LUBEL_DROME (91-396): 1.81e-65: 233: 22.19
+	Dm
		1214032 Q9W418_DROME (229-685): 0: 557: 99.78		LUBEL_DROME (91-396): 1.81e-65: 233: 22.19
+	Sc
		477225 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		HEL1_YEAST (98-541): 2.35e-128: 388: 30.22
+	Hs
		312457 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		ARI2_HUMAN (53-545): 6.02e-149: 438: 31.26
+	Mm
		476729 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RN216_MOUSE (90-401): 1.3e-66: 233: 15.57
+	Hs
		227107 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		PRKN_HUMAN (151-388): 3.75e-55: 194: 22.10
+	Hs
		475069 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		RN19B_HUMAN (170-396): 9.81e-68: 234: 25.82
+	Mm
		476959 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		RNF31_MOUSE (127-397): 1.06e-57: 210: 19.54
+	Rn
		1144287 UBC_RAT (1-108): 1.27e-29: 127: 90.74		PRKN_RAT (151-388): 1.07e-54: 193: 22.85
+	Hs
		226251 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		PRKN_HUMAN (151-388): 3.75e-55: 194: 22.10
+	Hs
		171468 UBD_HUMAN (155-304): 5.41e-28: 112: 32.05		PRKN_HUMAN (151-388): 3.75e-55: 194: 22.10
+	Hs
		226334 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		PRKN_HUMAN (151-388): 3.75e-55: 194: 22.10