HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UBP16 (Q9Y5T5)
Ubiquitin carboxyl-terminal hydrolase 16 (EC 3.4.19.12) (Deubiquitinating enzyme 16) (Ubiquitin thioesterase 16) (Ubiquitin-processing protease UBP-M) (Ubiquitin-specific-processing protease 16)
Gene: USP16

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.968

Property	Details
Experiments	28190767, 29576527, 32110315, 33141564, 34642328, 17512543, 22195557, 15171253, 23287719
Identification Methods	pull down, affinity chromatography technology, unspecified method, enzymatic study
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UCH~ubiquitin, ubiquitin~zf-UBP
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 823
+	Hs
		475957 UBC_HUMAN (1-685): 0: 846: 100.00		UBP45_HUMAN (3-823): 2.47e-153: 470: 37.06
+	Hs
		476097 UBC_HUMAN (1-685): 0: 846: 100.00		UBP33_HUMAN (5-821): 2.01e-115: 374: 18.01
+	Hs
		476599 UBC_HUMAN (1-685): 0: 846: 100.00		UBP20_HUMAN (17-821): 3.01e-112: 365: 18.72
+	Hs
		475461 UBC_HUMAN (1-685): 0: 846: 100.00		UBP5_HUMAN (32-822): 8.58e-81: 279: 12.79
+	Hs
		475990 UBC_HUMAN (1-685): 0: 846: 100.00		UBP37_HUMAN (91-819): 1.96e-79: 277: 14.66
+	Hs
		296262 UBC_HUMAN (1-685): 0: 846: 100.00		UBP1_HUMAN (122-802): 7.03e-69: 244: 17.82
+	Hs
		301354 UBC_HUMAN (1-685): 0: 846: 100.00		UBP19_HUMAN (611-821): 4.19e-52: 199: 28.64
+	Hs
		476579 UBC_HUMAN (1-685): 0: 846: 100.00		UBP22_HUMAN (454-823): 6.46e-48: 180: 19.42
+	Hs
		271022 UBC_HUMAN (1-685): 0: 846: 100.00		UBP2_HUMAN (629-820): 1.25e-39: 157: 26.94
+	Hs
		476658 UBC_HUMAN (1-685): 0: 846: 100.00		UBP3_HUMAN (527-819): 1.63e-37: 149: 22.19
+	Hs
		475403 UBC_HUMAN (1-685): 0: 846: 100.00		UBP6_HUMAN (727-821): 5.37e-16: 85.2: 21.05
+	Hs
		476067 UBC_HUMAN (1-685): 0: 846: 100.00		UBP32_HUMAN (727-821): 7.28e-16: 84.8: 21.05
+	Hs
		64200 UBC_HUMAN (1-685): 0: 846: 100.00		UBP27_HUMAN (632-821): 6.68e-16: 82.8: 27.64
+	Hs
		475502 UBC_HUMAN (1-685): 0: 846: 100.00		UBP11_HUMAN (393-556): 2.64e-11: 69.4: 8.82
+	Hs
		475693 UBC_HUMAN (1-685): 0: 846: 100.00		UBP4_HUMAN (395-571): 3.45e-10: 65.9: 5.50
+	Hs
		476624 UBC_HUMAN (1-685): 0: 846: 100.00		UBP15_HUMAN (388-558): 4.48e-10: 65.5: 7.47
+	Hs
		475954 UBC_HUMAN (1-685): 0: 846: 100.00		UBP31_HUMAN (390-625): 1.76e-09: 63.6: 11.42
+	Dm
		477538 UBIQP_DROME (1-610): 0: 752: 99.84		NOT_DROME (464-821): 7.29e-40: 156: 18.38
+	At
		1210479 UBQ10_ARATH (305-685): 2.63e-153: 453: 95.80		UBP15_ARATH (632-821): 2.14e-18: 92.4: 33.16
+	Sc
		477366 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBP8_YEAST (629-819): 7.6e-18: 89.4: 33.16