HitPredict

Interactor 1: UBC (P0CG50)
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]
Gene: UBC

Interactor 2: SQSTM (Q64337)
Sequestosome-1 (STONE14) (Ubiquitin-binding protein p62)
Gene: Sqstm1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.714

Property	Details
Experiments	21715324, 28190767, 29676259, 31362587, 23637164
Identification Methods	pull down, x-ray crystallography, affinity chromatography technology
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 734 Mm			1 442
+	Hs
		475720 UBC_HUMAN (77-724): 0: 790: 97.22		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Mm
		476925 UBC_MOUSE (1-734): 0: 912: 100.00		MIB2_MOUSE (106-206): 3.85e-13: 73.6: 28.16
+	Mm
		476802 UBC_MOUSE (1-734): 0: 912: 100.00		HERC2_MOUSE (120-197): 1.06e-11: 69.4: 32.50
+	Rn
		89006 UBC_RAT (1-724): 0: 898: 97.51		D4ACN3_RAT (120-197): 1.08e-11: 69.4: 32.50
+	Hs
		476011 UBC_HUMAN (77-724): 0: 790: 97.22		MIB1_HUMAN (105-228): 1.65e-27: 117: 27.69
+	Hs
		923979 RS27A_HUMAN (609-684): 3.67e-42: 152: 100.00		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		476162 UBC_HUMAN (77-724): 0: 790: 97.22		MIB2_HUMAN (106-219): 7.47e-14: 75.9: 27.59
+	Hs
		319697 UBC_HUMAN (77-724): 0: 790: 97.22		HERC2_HUMAN (120-197): 1.35e-11: 69: 32.50
+	Hs
		397952 ISG15_HUMAN (228-380): 5.84e-29: 115: 32.69		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		171495 UBD_HUMAN (155-304): 2.52e-28: 113: 32.05		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Hs
		475023 UBB_HUMAN (1-77): 3.45e-27: 112: 98.70		SQSTM_HUMAN (1-442): 0: 715: 89.82
+	Xl
		1151527 Q7SY79_XENLA (153-724): 0: 707: 96.85		MIB1_XENLA (105-228): 2.16e-27: 117: 27.69
+	Dr
		47652 Q6IS68_DANRE (1-534): 0: 672: 99.63		A0AR23_DANRE (106-219): 6.95e-13: 72.9: 25.00
+	Dr
		47643 F1QHN6_DANRE (229-724): 0: 602: 96.37		A0AR23_DANRE (106-219): 6.95e-13: 72.9: 25.00
+	Dr
		47653 Q7SXA3_DANRE (609-684): 1.83e-42: 152: 100.00		A0AR23_DANRE (106-219): 6.95e-13: 72.9: 25.00