HitPredict

Interactor 1: UBC (P0CG50)
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]
Gene: UBC

Interactor 2: UCHL1 (Q9R0P9)
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) (EC 3.4.19.12) (Neuron cytoplasmic protein 9.5) (PGP 9.5) (PGP9.5) (Ubiquitin thioesterase L1)
Gene: UCHL1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.806

Property	Details
Experiments	28190767, 12913066
Identification Methods	pull down, biochemical
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	Peptidase_C12~ubiquitin
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0043209 - myelin sheath
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 734 Mm			1 223
+	Mm
		477056 UBC_MOUSE (1-734): 0: 912: 100.00		UCHL5_MOUSE (2-220): 4.41e-101: 297: 22.12
+	Mm
		477030 UBC_MOUSE (1-734): 0: 912: 100.00		UCHL3_MOUSE (2-222): 3.64e-100: 291: 53.98
+	Mm
		476730 UBC_MOUSE (1-734): 0: 912: 100.00		UCHL4_MOUSE (2-222): 1.15e-96: 283: 52.40
+	Rn
		962731 UBC_RAT (1-724): 0: 898: 97.51		UCHL1_RAT (1-223): 1.11e-101: 295: 100.00
+	Hs
		456475 UBC_HUMAN (77-724): 0: 790: 97.22		UCHL1_HUMAN (1-223): 1.02e-102: 298: 95.52
+	Hs
		476639 UBC_HUMAN (77-724): 0: 790: 97.22		UCHL5_HUMAN (2-220): 1.14e-100: 296: 22.12
+	Hs
		475307 UBC_HUMAN (77-724): 0: 790: 97.22		UCHL3_HUMAN (2-222): 1.19e-100: 293: 53.10
+	Hs
		476130 UBC_HUMAN (77-724): 0: 790: 97.22		BAP1_HUMAN (3-220): 4.12e-78: 250: 22.69
+	Sc
		477215 UBI4P_YEAST (381-724): 5.74e-136: 407: 90.99		UBL1_YEAST (5-219): 2.06e-55: 178: 27.16
+	Hs
		456536 RS27A_HUMAN (609-684): 3.67e-42: 152: 100.00		UCHL1_HUMAN (1-223): 1.02e-102: 298: 95.52
+	Hs
		398154 ISG15_HUMAN (228-380): 5.84e-29: 115: 32.69		UCHL5_HUMAN (2-220): 1.14e-100: 296: 22.12
+	Hs
		456474 UBB_HUMAN (1-77): 3.45e-27: 112: 98.70		UCHL1_HUMAN (1-223): 1.02e-102: 298: 95.52
+	Hs
		474910 UBB_HUMAN (1-77): 3.45e-27: 112: 98.70		UCHL3_HUMAN (2-222): 1.19e-100: 293: 53.10
+	Hs
		548107 Q5U5U6_HUMAN (1-77): 3.45e-27: 112: 98.70		UCHL3_HUMAN (2-222): 1.19e-100: 293: 53.10
+	Hs
		924096 RS27A_HUMAN (609-684): 3.67e-42: 152: 100.00		BAP1_HUMAN (3-220): 4.12e-78: 250: 22.69