HitPredict

Interactor 1: UBC (P0CG50)
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]
Gene: UBC

Interactor 2: IKKE (Q9R0T8)
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
Gene: Ikbke

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24882218
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 734 Mm			1 717
+	Mm
		476818 UBC_MOUSE (1-734): 0: 912: 100.00		IKKA_MOUSE (9-711): 4.14e-122: 383: 17.35
+	Mm
		291435 UBC_MOUSE (1-734): 0: 912: 100.00		IKKB_MOUSE (9-702): 8.98e-120: 377: 19.37
+	Hs
		475745 UBC_HUMAN (77-724): 0: 790: 97.22		IKKE_HUMAN (1-717): 3.38e-161: 483: 82.34
+	Hs
		476524 UBC_HUMAN (77-724): 0: 790: 97.22		TBK1_HUMAN (1-717): 9.06e-158: 475: 46.07
+	Hs
		158377 UBC_HUMAN (77-724): 0: 790: 97.22		IKKB_HUMAN (9-702): 9.46e-134: 414: 18.37
+	Hs
		167451 UBC_HUMAN (77-724): 0: 790: 97.22		IKKA_HUMAN (9-711): 3.05e-122: 384: 17.03
+	Mm
		250791 UBC_MOUSE (1-734): 0: 912: 100.00		ULK1_MOUSE (1-221): 1.83e-22: 105: 30.70
+	Hs
		262227 UBC_HUMAN (77-724): 0: 790: 97.22		ULK1_HUMAN (13-221): 1.14e-22: 105: 32.41
+	Hs
		475511 UBC_HUMAN (77-724): 0: 790: 97.22		DAPK1_HUMAN (2-222): 1.36e-20: 99.4: 31.42
+	At
		1091642 UBQ3_ARATH (457-724): 7.39e-99: 308: 89.55		CDPKB_ARATH (5-518): 1.57e-121: 374: 14.67
+	At
		1091646 UBQ3_ARATH (457-724): 7.39e-99: 308: 89.55		MPK4_ARATH (12-351): 1.64e-123: 374: 15.56
+	At
		1091641 UBQ3_ARATH (457-724): 7.39e-99: 308: 89.55		KIN10_ARATH (3-442): 1.68e-120: 372: 19.33
+	At
		955189 UBQ3_ARATH (457-724): 7.39e-99: 308: 89.55		KIN11_ARATH (9-481): 1.08e-115: 359: 18.52
+	At
		1091896 UBQ3_ARATH (457-724): 7.39e-99: 308: 89.55		SRK2E_ARATH (5-352): 2.37e-106: 330: 20.06
+	Hs
		475222 UBB_HUMAN (1-77): 3.45e-27: 112: 98.70		TBK1_HUMAN (1-717): 9.06e-158: 475: 46.07
+	Hs
		625332 RS27A_HUMAN (609-684): 3.67e-42: 152: 100.00		CDK2_HUMAN (6-312): 1.35e-126: 379: 21.61
+	Hs
		397911 ISG15_HUMAN (228-380): 5.84e-29: 115: 32.69		CDK3_HUMAN (6-309): 4.56e-122: 368: 20.20
+	At
		98421 UBQ3_ARATH (457-724): 7.39e-99: 308: 89.55		RUK_ARATH (9-222): 5.61e-23: 107: 35.19