HitPredict

Interactor 1: UBA6 (A0AVT1)
Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2)
Gene: UBA6

Interactor 2: UBD (O15205)
Ubiquitin D (Diubiquitin) (Ubiquitin-like protein FAT10)
Gene: UBD

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.849

Property	Details
Experiments	22427669, 25422469, 20975683
Identification Methods	pull down, enzymatic study, affinity chromatography technology, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	ThiF~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1052 Hs			1 165
+	Hs
		48090 UBA6_HUMAN (1-1052): 0: 1156: 100.00		UBC_HUMAN (8-165): 1.36e-60: 200: 31.01
+	Hs
		475337 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UBC_HUMAN (8-165): 1.36e-60: 200: 31.01
+	Mm
		476902 UBA6_MOUSE (1-1052): 0: 1136: 89.07		UBC_MOUSE (8-165): 1.15e-60: 201: 31.01
+	Mm
		476770 UBA1_MOUSE (1-1045): 0: 1126: 40.83		UBC_MOUSE (8-165): 1.15e-60: 201: 31.01
+	Hs
		171474 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UBD_HUMAN (1-165): 1.64e-43: 143: 100.00
+	Hs
		607051 UBA1_HUMAN (1-1045): 0: 1139: 40.92		RS27A_HUMAN (90-165): 1.3e-32: 115: 35.53
+	Rn
		1137285 UBA1_RAT (1-1045): 0: 1128: 41.20		UBC_RAT (5-118): 2.5e-33: 125: 24.56
+	At
		955613 UBE11_ARATH (32-1047): 0: 1025: 37.44		UBQ3_ARATH (8-165): 5.48e-63: 197: 30.38
+	Sc
		477133 UBA1_YEAST (24-1046): 0: 979: 40.52		UBI4P_YEAST (5-84): 9.34e-28: 108: 26.25
+	Hs
		397822 UBA7_HUMAN (34-1045): 0: 905: 36.34		ISG15_HUMAN (8-87): 1.38e-10: 58.5: 21.25
+	Hs
		476506 SAE2_HUMAN (49-418): 1.82e-78: 272: 13.64		UBC_HUMAN (8-165): 1.36e-60: 200: 31.01
+	Hs
		171508 SAE2_HUMAN (49-418): 1.82e-78: 272: 13.64		UBD_HUMAN (1-165): 1.64e-43: 143: 100.00
+	Hs
		171506 SAE1_HUMAN (427-692): 3.45e-58: 206: 15.36		UBD_HUMAN (1-165): 1.64e-43: 143: 100.00
+	Rn
		1144252 UBA3_RAT (852-1017): 5.69e-40: 156: 19.19		UBC_RAT (5-118): 2.5e-33: 125: 24.56
+	Sc
		477515 UBA3_YEAST (463-640): 6.31e-23: 102: 32.80		UBI4P_YEAST (5-84): 9.34e-28: 108: 26.25
+	At
		790154 AXR1_ARATH (162-427): 8.46e-17: 87.2: 17.52		RUB1_ARATH (5-83): 7.46e-25: 95.3: 24.05