HitPredict

Interactor 1: UBA6 (A0AVT1)
Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2)
Gene: UBA6

Interactor 2: UB2D3 (P61077)
Ubiquitin-conjugating enzyme E2 D3 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D3) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D3) (Ubiquitin carrier protein D3) (Ubiquitin-conjugating enzyme E2(17)KB 3) (Ubiquitin-conjugating enzyme E2-17 kDa 3) (Ubiquitin-protein ligase D3)
Gene: UBE2D3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	17597759
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1052 Hs			1 147
+	Hs
		48104 UBA6_HUMAN (1-1052): 0: 1156: 100.00		UB2D1_HUMAN (1-147): 2.87e-82: 239: 88.44
+	Hs
		48107 UBA6_HUMAN (1-1052): 0: 1156: 100.00		UB2D2_HUMAN (1-147): 4.16e-82: 239: 97.28
+	Hs
		607190 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2D4_HUMAN (1-147): 8.97e-83: 241: 91.84
+	Hs
		607026 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2D1_HUMAN (1-147): 2.87e-82: 239: 88.44
+	Hs
		607050 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2D2_HUMAN (1-147): 4.16e-82: 239: 97.28
+	Hs
		607039 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2D3_HUMAN (1-147): 5.79e-81: 236: 100.00
+	Hs
		607136 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2E2_HUMAN (4-146): 1.76e-74: 222: 65.04
+	Hs
		607129 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2E3_HUMAN (4-146): 1.05e-73: 220: 65.73
+	Hs
		607028 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2E1_HUMAN (4-146): 2.18e-72: 216: 65.04
+	Hs
		607023 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UBE2A_HUMAN (2-144): 3.97e-70: 209: 39.16
+	Hs
		607054 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UBE2B_HUMAN (2-144): 1.8e-69: 208: 37.76
+	Hs
		607042 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UBE2N_HUMAN (4-147): 3.74e-68: 204: 46.53
+	Sp
		293848 UBA1_SCHPO (26-1043): 0: 995: 40.25		UBC4_SCHPO (1-147): 4.55e-80: 234: 84.35
+	Sc
		549788 UBA1_YEAST (24-1046): 0: 979: 40.52		UBC4_YEAST (3-147): 3.86e-79: 232: 80.00
+	Sp
		251976 UBA1_SCHPO (26-1043): 0: 995: 40.25		UBC1_SCHPO (4-146): 2.58e-44: 146: 45.14
+	Sp
		293851 UBA1_SCHPO (26-1043): 0: 995: 40.25		UBC14_SCHPO (6-146): 4.15e-43: 141: 46.48
+	Dm
		715098 Q8T0L3_DROME (21-1045): 0: 990: 40.89		UBE2N_DROME (4-147): 3.72e-44: 143: 48.61
+	Hs
		782203 UBA7_HUMAN (34-1045): 0: 905: 36.34		UB2E1_HUMAN (4-146): 2.18e-72: 216: 65.04
+	Hs
		1282360 SAE2_HUMAN (49-418): 1.82e-78: 272: 13.64		UB2E3_HUMAN (4-146): 1.05e-73: 220: 65.73
+	Hs
		919796 UBA3_HUMAN (852-1017): 4.6e-40: 156: 19.19		UB2D2_HUMAN (1-147): 4.16e-82: 239: 97.28