HitPredict

Interactor 1: UBA6 (A0AVT1)
Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2)
Gene: UBA6

Interactor 2: UB2L3 (P68036)
Ubiquitin-conjugating enzyme E2 L3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L3) (L-UBC) (UbcH7) (Ubiquitin carrier protein L3) (Ubiquitin-conjugating enzyme E2-F1) (Ubiquitin-protein ligase L3)
Gene: UBE2L3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.888

Property	Details
Experiments	29643511, 19250909, 36758106, 17597759
Identification Methods	pull down, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	E1_UFD~UQ_con, ThiF~UQ_con
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process and 1 others more... GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1052 Hs			1 154
+	Hs
		48104 UBA6_HUMAN (1-1052): 0: 1156: 100.00		UB2D1_HUMAN (2-149): 5.66e-75: 221: 38.26
+	Hs
		48107 UBA6_HUMAN (1-1052): 0: 1156: 100.00		UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58
+	Hs
		48106 UBA6_HUMAN (1-1052): 0: 1156: 100.00		UB2D3_HUMAN (2-149): 8.29e-74: 218: 36.91
+	Hs
		607190 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2D4_HUMAN (2-149): 6.75e-76: 224: 38.93
+	Hs
		607026 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2D1_HUMAN (2-149): 5.66e-75: 221: 38.26
+	Hs
		607050 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58
+	Hs
		607039 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2D3_HUMAN (2-149): 8.29e-74: 218: 36.91
+	Hs
		607129 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2E3_HUMAN (2-149): 2.39e-68: 207: 34.90
+	Hs
		607136 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2E2_HUMAN (2-149): 1.55e-68: 207: 34.90
+	Hs
		607028 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2E1_HUMAN (2-149): 6.55e-67: 203: 34.90
+	Hs
		607023 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UBE2A_HUMAN (3-150): 7.79e-65: 196: 26.17
+	Hs
		607057 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2L3_HUMAN (1-154): 1.26e-64: 196: 100.00
+	Hs
		607054 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UBE2B_HUMAN (3-148): 8.21e-64: 193: 26.53
+	Hs
		48080 UBA6_HUMAN (1-1052): 0: 1156: 100.00		UB2L6_HUMAN (1-152): 4e-53: 166: 55.26
+	Hs
		159017 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UB2L6_HUMAN (1-152): 4e-53: 166: 55.26
+	Hs
		48135 UBA6_HUMAN (1-1052): 0: 1156: 100.00		UBE2T_HUMAN (43-151): 2.92e-25: 97.1: 40.18
+	Hs
		607169 UBA1_HUMAN (1-1045): 0: 1139: 40.92		UBE2T_HUMAN (43-151): 2.92e-25: 97.1: 40.18
+	Sp
		293848 UBA1_SCHPO (26-1043): 0: 995: 40.25		UBC4_SCHPO (2-148): 1.36e-73: 218: 37.84
+	Sp
		293851 UBA1_SCHPO (26-1043): 0: 995: 40.25		UBC14_SCHPO (7-149): 2.42e-28: 103: 36.11
+	Dm
		715098 Q8T0L3_DROME (21-1045): 0: 990: 40.89		UBE2N_DROME (5-148): 5.03e-25: 95.5: 35.17