HitPredict

Interactor 1: UBA6 (A0AVT1)
Ubiquitin-like modifier-activating enzyme 6 (Ubiquitin-activating enzyme 6) (EC 6.2.1.45) (Monocyte protein 4) (MOP-4) (Ubiquitin-activating enzyme E1-like protein 2) (E1-L2)
Gene: UBA6

Interactor 2: HERC5 (Q9UII4)
E3 ISG15--protein ligase HERC5 (EC 2.3.2.-) (Cyclin-E-binding protein 1) (HECT domain and RCC1-like domain-containing protein 5)
Gene: HERC5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35671810
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1052 Hs			1 1024
+	Hs
		607185 UBA1_HUMAN (1-1045): 0: 1139: 40.92		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		48079 UBA6_HUMAN (1-1052): 0: 1156: 100.00		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		48128 UBA6_HUMAN (1-1052): 0: 1156: 100.00		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Hs
		125155 UBA1_HUMAN (1-1045): 0: 1139: 40.92		WWP2_HUMAN (599-1024): 1.14e-167: 516: 22.02
+	Hs
		607135 UBA1_HUMAN (1-1045): 0: 1139: 40.92		ITCH_HUMAN (593-1024): 1.76e-165: 511: 24.22
+	Hs
		1354311 SAE2_HUMAN (49-418): 1.82e-78: 272: 13.64		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		1353972 SAE1_HUMAN (427-692): 3.45e-58: 206: 15.36		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		1252665 UBA3_HUMAN (852-1017): 4.6e-40: 156: 19.19		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		1039446 ULA1_HUMAN (220-431): 3.1e-16: 85.2: 16.25		HERC5_HUMAN (1-1024): 0: 1123: 100.00
+	Hs
		983261 SAE2_HUMAN (49-418): 1.82e-78: 272: 13.64		UBE3A_HUMAN (414-1024): 1.12e-172: 529: 25.37
+	Hs
		983260 SAE1_HUMAN (427-692): 3.45e-58: 206: 15.36		UBE3A_HUMAN (414-1024): 1.12e-172: 529: 25.37