HitPredict

Interactor 1: HS71A (P0DMV8)
Heat shock 70 kDa protein 1A (Heat shock 70 kDa protein 1) (HSP70-1) (HSP70.1) (Heat shock protein family A member 1A)
Gene: HSPA1A

Interactor 2: BIP (P11021)
Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
Gene: HSPA5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

The method score is based on:

Property	Details
Experiments	26496610
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

The annotation score is based on:

Property	Details
Interacting Pfam domains	HSP70~HSP70
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005783 - endoplasmic reticulum and 18 others more... GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0016887 - ATP hydrolysis activity GO:0019899 - enzyme binding GO:0030512 - negative regulation of transforming growth factor beta receptor signaling pathway GO:0031072 - heat shock protein binding GO:0031625 - ubiquitin protein ligase binding GO:0032991 - protein-containing complex GO:0042026 - protein refolding GO:0043066 - negative regulation of apoptotic process GO:0044183 - protein folding chaperone GO:0045296 - cadherin binding GO:0051082 - unfolded protein binding GO:0051085 - chaperone cofactor-dependent protein refolding GO:0051787 - misfolded protein binding GO:0070062 - extracellular exosome GO:0140662 - ATP-dependent protein folding chaperone
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1	641
Hs

1	654

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Last updated: 15 Jul 2024