HitPredict

Interactor 1: HS71B (P0DMV9)
Heat shock 70 kDa protein 1B (Heat shock 70 kDa protein 2) (HSP70-2) (HSP70.2) (Heat shock protein family A member 1B)
Gene: HSPA1B

Interactor 2: DNJB4 (Q9UDY4)
DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog) (HSP40 homolog) (Heat shock protein 40 homolog) (Human liver DnaJ-like protein)
Gene: DNAJB4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	DnaJ~HSP70
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0051082 - unfolded protein binding GO:0051085 - chaperone cofactor-dependent protein refolding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 641 Hs			1 337
+	Hs
		714088 HS71L_HUMAN (2-641): 0: 994: 89.06		DNJB4_HUMAN (1-337): 9.06e-140: 400: 100.00
+	Hs
		564203 HSP76_HUMAN (6-641): 0: 988: 82.55		DNJB4_HUMAN (1-337): 9.06e-140: 400: 100.00
+	Hs
		279280 HS71L_HUMAN (2-641): 0: 994: 89.06		DNJB5_HUMAN (1-337): 1.41e-131: 380: 60.92
+	Hs
		279274 HSP76_HUMAN (6-641): 0: 988: 82.55		DNJB5_HUMAN (1-337): 1.41e-131: 380: 60.92
+	Hs
		279272 HSP7C_HUMAN (1-613): 0: 984: 86.62		DNJB5_HUMAN (1-337): 1.41e-131: 380: 60.92
+	Hs
		636256 HS71L_HUMAN (2-641): 0: 994: 89.06		DNJB1_HUMAN (1-335): 7.26e-127: 368: 64.60
+	Hs
		564008 HSP76_HUMAN (6-641): 0: 988: 82.55		DNJB1_HUMAN (1-335): 7.26e-127: 368: 64.60
+	Hs
		483773 HS71B_HUMAN (1-641): 0: 987: 100.00		DNJB1_HUMAN (1-335): 7.26e-127: 368: 64.60
+	Hs
		503463 HSP7C_HUMAN (1-613): 0: 984: 86.62		DNJB1_HUMAN (1-335): 7.26e-127: 368: 64.60
+	Hs
		243312 HS71L_HUMAN (2-641): 0: 994: 89.06		DNJA2_HUMAN (2-336): 8.37e-120: 353: 31.46
+	Hs
		681341 HS71L_HUMAN (2-641): 0: 994: 89.06		DNJA1_HUMAN (5-335): 9.73e-119: 349: 32.17
+	Hs
		243284 HSP76_HUMAN (6-641): 0: 988: 82.55		DNJA2_HUMAN (2-336): 8.37e-120: 353: 31.46
+	Hs
		243275 HSP7C_HUMAN (1-613): 0: 984: 86.62		DNJA2_HUMAN (2-336): 8.37e-120: 353: 31.46
+	Hs
		564015 HSP76_HUMAN (6-641): 0: 988: 82.55		DNJA1_HUMAN (5-335): 9.73e-119: 349: 32.17
+	Hs
		483775 HS71B_HUMAN (1-641): 0: 987: 100.00		DNJA1_HUMAN (5-335): 9.73e-119: 349: 32.17
+	Hs
		503527 HSP7C_HUMAN (1-613): 0: 984: 86.62		DNJA1_HUMAN (5-335): 9.73e-119: 349: 32.17
+	Hs
		564136 HSP76_HUMAN (6-641): 0: 988: 82.55		DNJA4_HUMAN (5-336): 1.32e-116: 344: 31.12
+	Hs
		714087 HS71L_HUMAN (2-641): 0: 994: 89.06		DJB11_HUMAN (2-334): 6.07e-99: 298: 31.34
+	Hs
		564202 HSP76_HUMAN (6-641): 0: 988: 82.55		DJB11_HUMAN (2-334): 6.07e-99: 298: 31.34
+	Hs
		564137 HSP76_HUMAN (6-641): 0: 988: 82.55		DNJB3_HUMAN (4-108): 5.57e-28: 108: 55.56