HitPredict

Interactor 1: CALM1 (P0DP23)
Calmodulin-1
Gene: CALM1

Interactor 2: KCC1A (Q14012)
Calcium/calmodulin-dependent protein kinase type 1 (EC 2.7.11.17) (CaM kinase I) (CaM-KI) (CaM kinase I alpha) (CaMKI-alpha)
Gene: CAMK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	EF-hand_7~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0071902 - positive regulation of protein serine/threonine kinase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 149 Hs			1 370
+	Hs
		648500 CALL3_HUMAN (1-149): 1.98e-53: 167: 84.56		KCC1A_HUMAN (1-370): 6.16e-166: 469: 100.00
+	Hs
		483947 CALM1_HUMAN (1-149): 1.99e-56: 174: 100.00		KCC1D_HUMAN (3-326): 6.16e-148: 424: 82.10
+	Hs
		648542 CALL3_HUMAN (1-149): 1.98e-53: 167: 84.56		KCC1D_HUMAN (3-326): 6.16e-148: 424: 82.10
+	Hs
		483926 CALM1_HUMAN (1-149): 1.99e-56: 174: 100.00		KCC2B_HUMAN (16-365): 2.88e-140: 415: 35.79
+	Hs
		484000 CALM2_HUMAN (1-149): 1.99e-56: 174: 100.00		KCC2B_HUMAN (16-365): 2.88e-140: 415: 35.79
+	Hs
		484118 CALM3_HUMAN (1-149): 1.99e-56: 174: 100.00		KCC2B_HUMAN (16-365): 2.88e-140: 415: 35.79
+	At
		483086 CALM4_ARATH (1-149): 1.59e-53: 167: 89.26		CDPK3_ARATH (11-370): 1.68e-142: 416: 35.71
+	At
		886549 CALM7_ARATH (1-149): 1.98e-53: 167: 89.93		CDPK3_ARATH (11-370): 1.68e-142: 416: 35.71
+	Ce
		183804 CALM_CAEEL (1-149): 2.09e-55: 172: 97.99		CMK1_CAEEL (5-342): 6.62e-143: 410: 62.54
+	Dm
		825619 CALL_DROME (3-149): 9.23e-57: 175: 66.67		KCC2A_DROME (16-339): 1.01e-136: 401: 38.53
+	Dm
		906677 CALM_DROME (1-149): 5.63e-56: 173: 97.99		Q7JMV3_DROME (12-344): 4.28e-139: 403: 58.17
+	Hs
		483928 CALM1_HUMAN (1-149): 1.99e-56: 174: 100.00		KCC2D_HUMAN (15-344): 1.44e-136: 400: 38.14
+	Hs
		484002 CALM2_HUMAN (1-149): 1.99e-56: 174: 100.00		KCC2D_HUMAN (15-344): 1.44e-136: 400: 38.14
+	Hs
		484120 CALM3_HUMAN (1-149): 1.99e-56: 174: 100.00		KCC2D_HUMAN (15-344): 1.44e-136: 400: 38.14
+	Dm
		906661 CALM_DROME (1-149): 5.63e-56: 173: 97.99		KCC2A_DROME (16-339): 1.01e-136: 401: 38.53
+	At
		483166 CALM4_ARATH (1-149): 1.59e-53: 167: 89.26		CDPKA_ARATH (10-370): 1.64e-136: 401: 32.60
+	Hs
		483927 CALM1_HUMAN (1-149): 1.99e-56: 174: 100.00		KCC2G_HUMAN (18-313): 8.19e-72: 235: 41.81
+	Hs
		484001 CALM2_HUMAN (1-149): 1.99e-56: 174: 100.00		KCC2G_HUMAN (18-313): 8.19e-72: 235: 41.81
+	Hs
		484119 CALM3_HUMAN (1-149): 1.99e-56: 174: 100.00		KCC2G_HUMAN (18-313): 8.19e-72: 235: 41.81
+	Hs
		648497 CALL3_HUMAN (1-149): 1.98e-53: 167: 84.56		KCC2G_HUMAN (18-313): 8.19e-72: 235: 41.81