Interactor 1: R1A (P0DTC1)
Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Host translation inhibitor nsp1 (Leader protein) (Non-structural protein 1) (nsp1); Non-structural protein 2 (nsp2) (p65 homolog); Papain-like protease nsp3 (EC 3.4.19.12) (EC 3.4.22.-) (Non-structural protein 3) (nsp3) (PL2-PRO) (Papain-like proteinase) (PL-PRO); Non-structural protein 4 (nsp4); 3C-like proteinase nsp5 (3CL-PRO) (3CLp) (EC 3.4.22.69) (Main protease) (Mpro) (Non-structural protein 5) (nsp5) (SARS coronavirus main proteinase); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); Non-structural protein 8 (nsp8); RNA-capping enzyme subunit nsp9 (Non-structural protein 9) (nsp9) (EC 2.7.7.50); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL); Non-structural protein 11 (nsp11)]
Gene: R1A
Interactor 2: R1AB (P0DTD1)
Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor nsp1 (Leader protein) (Non-structural protein 1) (nsp1); Non-structural protein 2 (nsp2) (p65 homolog); Papain-like protease nsp3 (EC 3.4.19.12) (EC 3.4.22.-) (Non-structural protein 3) (nsp3) (PL2-PRO) (Papain-like proteinase) (PL-PRO); Non-structural protein 4 (nsp4); 3C-like proteinase nsp5 (3CL-PRO) (3CLp) (EC 3.4.22.69) (Main protease) (Mpro) (Non-structural protein 5) (nsp5) (SARS coronavirus main proteinase); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); Non-structural protein 8 (nsp8); Viral protein genome-linked nsp9 (Non-structural protein 9) (nsp9) (RNA-capping enzyme subunit nsp9); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL); RNA-directed RNA polymerase nsp12 (Pol) (RdRp) (EC 2.7.7.48) (EC 2.7.7.50) (Non-structural protein 12) (nsp12); Helicase nsp13 (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (Non-structural protein 13) (nsp13); Guanine-N7 methyltransferase nsp14 (EC 2.1.1.56) (EC 3.1.13.-) (Non-structural protein 14) (nsp14) (Proofreading exoribonuclease nsp14) (ExoN); Uridylate-specific endoribonuclease nsp15 (EC 4.6.1.-) (NendoU) (Non-structural protein 15) (nsp15); 2'-O-methyltransferase nsp16 (EC 2.1.1.57) (Non-structural protein 16) (nsp16)]
Gene: rep
Species: Severe acute respiratory syndrome coronavirus 2
Source: biogrid
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.38 | 1.00 | 0.621 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 34781739 |
| Identification Methods | two hybrid |
| Interaction Type | direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | bCoV_NAB~bCoV_NAB, Macro~bCoV_NSP3_N, CoV_ExoN~CoV_NSP10, CoV_Methyltr_2~CoV_NSP10, CoV_NSP10~CoV_NSP10, CoV_NSP2_N~CoV_NSP2_N, CoV_NSP3_C~CoV_NSP3_C, CoV_NSP4_C~CoV_NSP4_C, CoV_NSP7~CoV_NSP7, CoV_NSP7~CoV_NSP8, CoV_NSP7~RdRP_1, CoV_NSP8~CoV_NSP8, CoV_NSP8~CoV_RPol_N, CoV_NSP8~RdRP_1, CoV_ExoN~CoV_NSP9, CoV_NSP9~CoV_NSP9, CoV_NSP9~CoV_RPol_N, CoV_NSP9~RdRP_1, CoV_peptidase~CoV_peptidase, Macro~Macro and 1 others
more... |
| Common GO terms | GO:0002151 - G-quadruplex RNA binding GO:0003727 - single-stranded RNA binding GO:0004197 - cysteine-type endopeptidase activity GO:0004843 - cysteine-type deubiquitinase activity GO:0006508 - proteolysis and 18 others more... |
| Homologous interactions | 5 |
Homologous interactions
Color coding for hit scores 
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Last updated: 15 Jul 2024
