Interactor 1: SPIKE (P0DTC2)
Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike protein S2; Spike protein S2']
Gene: S

Interactor 2: SPIKE (P0DTC2)
Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1; Spike protein S2; Spike protein S2']
Gene: S

Species: Severe acute respiratory syndrome coronavirus 2

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.999

The method score is based on:

Property Details
Experiments 32075877, 32155444, 888800000035, 33845483, 32887876, 32703908, 32661423, 32841605, 32805734, 32991842, 888800000079, 33154106, 34015061, 888800000094, 33128388, 33556147, 33177651, 32907861, 888800000150, 33731853 and 233 others

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Identification Methods x-ray crystallography, pull down, affinity chromatography technology, biochemical, proximity labelling technology, protein complementation assay, fluorescent resonance energy transfer, 3D electron microscopy, electron tomography, molecular sieving and 12 others

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Interaction Type association, direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains bCoV_S1_N~bCoV_S1_N, bCoV_S1_N~bCoV_S1_RBD, CoV_S1_C~bCoV_S1_N, CoV_S2~bCoV_S1_N, bCoV_S1_RBD~bCoV_S1_RBD, CoV_S1_C~bCoV_S1_RBD, CoV_S2~bCoV_S1_RBD, CoV_S1_C~CoV_S2, CoV_S2~CoV_S2
Common GO terms GO:0005886 - plasma membrane
GO:0016020 - membrane
GO:0019031 - viral envelope
GO:0019062 - virion attachment to host cell
GO:0019064 - fusion of virus membrane with host plasma membrane
and 16 others

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Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 1273
Sa

1 1273
+ Sa

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024