HitPredict - High confidence protein-protein interactions

Interactor 1: NCAP (P0DTC9)
Nucleoprotein (N) (Nucleocapsid protein) (NC) (Protein N)
Gene: N

Interactor 2: NCAP (P0DTC9)
Nucleoprotein (N) (Nucleocapsid protein) (NC) (Protein N)
Gene: N

Species: Severe acute respiratory syndrome coronavirus 2

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.99	1.00	0.998

Property	Details
Experiments	32838362, 33845483, 33782395, 888800000131, 34373319, 33997662, 888800000227, 34371045, 34709727, 34095780, 888800000639, 36202211, 35842466, 34578187, 888800000778, 34672954, 34671206, 34239064, 35783502, 34294141 and 38 others more... 32979942, 33039147, 36807437, 888800000946, 888800000950, 34765991, 36323732, 37011862, 36317101, 34665939, 888800001011, 32914439, 33794152, 33556408, 34462738, 33458462, 34517577, 888800001055, 888800001056, 36139141, 32654247, 38172120, 34381460, 37749713, 34901782, 888800001098, 888800001112, 32416961, 33511102, 33479198, 32901111, 33290746, unassigned2913, 33495715, 33837182, 33895773, 34161778, 34780058
Identification Methods	two hybrid, affinity chromatography technology, fluorescent resonance energy transfer, pull down, x-ray crystallography, biochemical, proximity labelling technology, protein complementation assay, molecular sieving, mass spectrometry study of hydrogen/deuterium exchange and 18 others more... cosedimentation in solution, classical fluorescence spectroscopy, cross-linking study, fluorescence recovery after photobleaching, fluorescence microscopy, ultraviolet-visible spectroscopy, dynamic light scattering, light microscopy, blue native page, x ray scattering, static light scattering, ion mobility mass spectrometry of complexes, anti tag coimmunoprecipitation, confocal microscopy, differential scanning calorimetry, solution state nmr, mass spectrometry studies of complexes, bimolecular fluorescence complementation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	CoV_nucleocap~CoV_nucleocap
Common GO terms	GO:0003723 - RNA binding GO:0005576 - extracellular region GO:0005737 - cytoplasm GO:0019013 - viral nucleocapsid GO:0019028 - viral capsid and 17 others more... GO:0019074 - viral RNA genome packaging GO:0032688 - negative regulation of interferon-beta production GO:0035613 - RNA stem-loop binding GO:0039709 - cytoplasmic capsid assembly GO:0042288 - MHC class I protein binding GO:0042612 - MHC class I protein complex GO:0042803 - protein homodimerization activity GO:0043232 - intracellular non-membrane-bounded organelle GO:0043655 - host extracellular space GO:0044172 - host cell endoplasmic reticulum-Golgi intermediate compartment GO:0044177 - host cell Golgi apparatus GO:0044220 - host cell perinuclear region of cytoplasm GO:0052572 - response to host immune response GO:0140311 - protein sequestering activity GO:0140693 - molecular condensate scaffold activity GO:1900227 - positive regulation of NLRP3 inflammasome complex assembly GO:1990904 - ribonucleoprotein complex
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	419
Sa

1	419

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Last updated: 15 Jul 2024