Interactor 1: NCAP (P0DTC9)
Nucleoprotein (N) (Nucleocapsid protein) (NC) (Protein N)
Gene: N
Interactor 2: R1AB (P0DTD1)
Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor nsp1 (Leader protein) (Non-structural protein 1) (nsp1); Non-structural protein 2 (nsp2) (p65 homolog); Papain-like protease nsp3 (EC 3.4.19.12) (EC 3.4.22.-) (Non-structural protein 3) (nsp3) (PL2-PRO) (Papain-like proteinase) (PL-PRO); Non-structural protein 4 (nsp4); 3C-like proteinase nsp5 (3CL-PRO) (3CLp) (EC 3.4.22.69) (Main protease) (Mpro) (Non-structural protein 5) (nsp5) (SARS coronavirus main proteinase); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); Non-structural protein 8 (nsp8); Viral protein genome-linked nsp9 (Non-structural protein 9) (nsp9) (RNA-capping enzyme subunit nsp9); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL); RNA-directed RNA polymerase nsp12 (Pol) (RdRp) (EC 2.7.7.48) (EC 2.7.7.50) (Non-structural protein 12) (nsp12); Helicase nsp13 (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (Non-structural protein 13) (nsp13); Guanine-N7 methyltransferase nsp14 (EC 2.1.1.56) (EC 3.1.13.-) (Non-structural protein 14) (nsp14) (Proofreading exoribonuclease nsp14) (ExoN); Uridylate-specific endoribonuclease nsp15 (EC 4.6.1.-) (NendoU) (Non-structural protein 15) (nsp15); 2'-O-methyltransferase nsp16 (EC 2.1.1.57) (Non-structural protein 16) (nsp16)]
Gene: rep
Species: Severe acute respiratory syndrome coronavirus 2
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.96 | 0.60 | 0.760 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 32838362, 35044811, 33781803, 34671206, 34294141, 34781739, 36806252, 888800000946, 37704626, 888800001056 |
| Identification Methods | two hybrid, affinity chromatography technology, x-ray crystallography, pull down, protein complementation assay, fluorescent resonance energy transfer, anti tag coimmunoprecipitation, microscale thermophoresis, molecular sieving |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0003723 - RNA binding GO:0044172 - host cell endoplasmic reticulum-Golgi intermediate compartment GO:0044177 - host cell Golgi apparatus GO:0044220 - host cell perinuclear region of cytoplasm |
| Homologous interactions | 1 |
Homologous interactions
Color coding for hit scores 
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| + | Sa |   |
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
