HitPredict

Interactor 1: R1AB (P0DTD1)
Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein) [Cleaved into: Host translation inhibitor nsp1 (Leader protein) (Non-structural protein 1) (nsp1); Non-structural protein 2 (nsp2) (p65 homolog); Papain-like protease nsp3 (EC 3.4.19.12) (EC 3.4.22.-) (Non-structural protein 3) (nsp3) (PL2-PRO) (Papain-like proteinase) (PL-PRO); Non-structural protein 4 (nsp4); 3C-like proteinase nsp5 (3CL-PRO) (3CLp) (EC 3.4.22.69) (Main protease) (Mpro) (Non-structural protein 5) (nsp5) (SARS coronavirus main proteinase); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); Non-structural protein 8 (nsp8); Viral protein genome-linked nsp9 (Non-structural protein 9) (nsp9) (RNA-capping enzyme subunit nsp9); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL); RNA-directed RNA polymerase nsp12 (Pol) (RdRp) (EC 2.7.7.48) (EC 2.7.7.50) (Non-structural protein 12) (nsp12); Helicase nsp13 (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (Non-structural protein 13) (nsp13); Guanine-N7 methyltransferase nsp14 (EC 2.1.1.56) (EC 3.1.13.-) (Non-structural protein 14) (nsp14) (Proofreading exoribonuclease nsp14) (ExoN); Uridylate-specific endoribonuclease nsp15 (EC 4.6.1.-) (NendoU) (Non-structural protein 15) (nsp15); 2'-O-methyltransferase nsp16 (EC 2.1.1.57) (Non-structural protein 16) (nsp16)]
Gene: rep

Interactor 2: NS7B (P0DTD8)
ORF7b protein (ORF7b) (Accessory protein 7b)
Gene: 7b

Species: Severe acute respiratory syndrome coronavirus 2

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.55	0.665

Property	Details
Experiments	34294141, 888800000946, 32838362, 34781739
Identification Methods	two hybrid, fluorescent resonance energy transfer, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane
Homologous interactions	0