HitPredict

Interactor 1: IF4A (P10081)
ATP-dependent RNA helicase eIF4A (EC 3.6.4.13) (Eukaryotic initiation factor 4A) (eIF-4A) (Stimulator factor I 37 kDa component) (Translation initiation factor 1/2) (p37)
Gene: TIF1

Interactor 2: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	31399574, 37968396, 15766533
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0016887 - ATP hydrolysis activity
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 395 Sc			1 705
+	Ca
		804473 IF4A_CANAL (2-394): 2.45e-173: 490: 78.17		HSP90_CANAL (4-705): 0: 953: 82.36
+	Sc
		365655 IF4A_YEAST (1-395): 9.95e-152: 435: 100.00		HSP82_YEAST (1-705): 0: 968: 95.63
+	Sc
		365837 DBP2_YEAST (1-392): 1.76e-131: 390: 31.42		HSP82_YEAST (1-705): 0: 968: 95.63
+	Sc
		415879 DED1_YEAST (3-395): 1.27e-125: 376: 30.19		HSC82_YEAST (1-705): 0: 977: 100.00
+	Sc
		365556 DED1_YEAST (3-395): 1.27e-125: 376: 30.19		HSP82_YEAST (1-705): 0: 968: 95.63
+	Sc
		543756 DHH1_YEAST (24-390): 2.1e-96: 298: 43.48		HSC82_YEAST (1-705): 0: 977: 100.00
+	Sc
		366306 DHH1_YEAST (24-390): 2.1e-96: 298: 43.48		HSP82_YEAST (1-705): 0: 968: 95.63
+	Ca
		804529 DHH1_CANAL (24-390): 1.19e-96: 300: 42.94		HSP90_CANAL (4-705): 0: 953: 82.36
+	Tc
		1116202 Q4DIE1_TRYCC (24-390): 1.11e-92: 285: 41.46		Q4CQS6_TRYCC (4-705): 0: 952: 62.36