Interactor 1: MED19 (A0JLT2)
Mediator of RNA polymerase II transcription subunit 19 (Lung cancer metastasis-related protein 1) (Mediator complex subunit 19)
Gene: MED19

Interactor 2: MED14 (O60244)
Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150)
Gene: MED14

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.970

The method score is based on:

Property Details
Experiments 24981860, 35271311, 26186194, 28514442, 15175163, 33961781, 21729782, 14576168
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Med14~Med19
Common GO terms GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0016592 - mediator complex
GO:0032968 - positive regulation of transcription elongation by RNA polymerase II
and 4 others

more...

Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 244
Hs

1 1454
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024