HitPredict

Interactor 1: AST4 (P10084)
Achaete-scute complex protein T4 (Protein scute)
Gene: sc

Interactor 2: ESM7 (P13097)
Enhancer of split m7 protein (E(spl)m7)
Gene: E(spl)m7-HLH

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.914

Property	Details
Experiments	22949507, 25694512, 9371806, 15507447, unassigned4
Identification Methods	two hybrid, affinity chromatography technology, experimental interaction detection
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0007399 - nervous system development GO:0043565 - sequence-specific DNA binding GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 345 Dm			1 186
+	Dm
		485926 AST4_DROME (17-345): 1.87e-122: 357: 100.00		ESMB_DROME (1-186): 7.96e-53: 168: 44.06
+	Dm
		485919 AST4_DROME (17-345): 1.87e-122: 357: 100.00		ESM8_DROME (7-186): 1.08e-51: 165: 40.00
+	Dm
		485927 AST4_DROME (17-345): 1.87e-122: 357: 100.00		ESMC_DROME (6-186): 2.48e-51: 165: 47.48
+	Dm
		485925 AST4_DROME (17-345): 1.87e-122: 357: 100.00		ESM3_DROME (3-186): 1.05e-44: 149: 35.56
+	Dm
		485917 AST4_DROME (17-345): 1.87e-122: 357: 100.00		ESM5_DROME (8-186): 3.79e-43: 143: 40.00
+	Dm
		454869 AST8_DROME (62-272): 6.16e-33: 129: 29.52		ESM7_DROME (1-186): 1.5e-64: 198: 100.00
+	Dm
		485886 AST5_DROME (72-170): 3.57e-24: 99.8: 52.94		ESM7_DROME (1-186): 1.5e-64: 198: 100.00
+	Dm
		454872 AST8_DROME (62-272): 6.16e-33: 129: 29.52		ESMB_DROME (1-186): 7.96e-53: 168: 44.06
+	Dm
		454873 AST8_DROME (62-272): 6.16e-33: 129: 29.52		ESMC_DROME (6-186): 2.48e-51: 165: 47.48
+	Dm
		454871 AST8_DROME (62-272): 6.16e-33: 129: 29.52		ESM3_DROME (3-186): 1.05e-44: 149: 35.56
+	Dm
		485892 AST5_DROME (72-170): 3.57e-24: 99.8: 52.94		ESMB_DROME (1-186): 7.96e-53: 168: 44.06
+	Dm
		485887 AST5_DROME (72-170): 3.57e-24: 99.8: 52.94		ESM8_DROME (7-186): 1.08e-51: 165: 40.00
+	Dm
		485893 AST5_DROME (72-170): 3.57e-24: 99.8: 52.94		ESMC_DROME (6-186): 2.48e-51: 165: 47.48
+	Mm
		485959 MYOD1_MOUSE (40-226): 2.27e-29: 116: 17.65		BHE41_MOUSE (5-181): 4.76e-37: 134: 23.98
+	Dm
		485891 AST5_DROME (72-170): 3.57e-24: 99.8: 52.94		ESM3_DROME (3-186): 1.05e-44: 149: 35.56
+	Hs
		546062 MYOD1_HUMAN (40-221): 5.55e-23: 99.4: 17.58		HEY1_HUMAN (7-180): 5.81e-44: 149: 22.40
+	Dm
		485885 AST5_DROME (72-170): 3.57e-24: 99.8: 52.94		ESM5_DROME (8-186): 3.79e-43: 143: 40.00
+	Rn
		583274 ASCL1_RAT (49-224): 5.19e-27: 108: 32.96		HES5_RAT (3-186): 7.87e-38: 129: 23.66
+	Hs
		146449 MYOD1_HUMAN (40-221): 5.55e-23: 99.4: 17.58		BHE40_HUMAN (6-181): 2.68e-37: 134: 22.44
+	Hs
		546043 MYOD1_HUMAN (40-221): 5.55e-23: 99.4: 17.58		BHE41_HUMAN (5-156): 4.49e-32: 121: 26.32