HitPredict

Interactor 1: RAP2A (P10114)
Ras-related protein Rap-2a (EC 3.6.5.2) (RbBP-30)
Gene: RAP2A

Interactor 2: GNDS (Q12967)
Ral guanine nucleotide dissociation stimulator (RalGDS) (Ral guanine nucleotide exchange factor) (RalGEF)
Gene: RALGDS

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	11786539, 28405688, 10085114
Identification Methods	two hybrid, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RA~Ras, Ras~RasGEF, Ras~RasGEF_N
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 183 Hs			1 914
+	Hs
		897981 RAP2B_HUMAN (1-182): 2.01e-82: 243: 91.21		GNDS_HUMAN (1-914): 0: 882: 100.00
+	Hs
		919618 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		GNDS_HUMAN (1-914): 0: 882: 100.00
+	Dm
		442968 RAP1_DROME (1-165): 8.23e-81: 239: 64.24		Q9GR11_DROME (65-887): 7.88e-171: 517: 27.52
+	Dm
		442959 RAP1_DROME (1-165): 8.23e-81: 239: 64.24		Q86BI2_DROME (65-887): 5.66e-170: 515: 27.40
+	Dm
		442969 RAP1_DROME (1-165): 8.23e-81: 239: 64.24		Q9U4U5_DROME (65-887): 4.47e-166: 511: 27.40
+	Hs
		486043 RAP2A_HUMAN (1-183): 7.32e-82: 241: 100.00		RPGF4_HUMAN (30-650): 4.1e-128: 412: 16.26
+	Hs
		919656 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		RPGF4_HUMAN (30-650): 4.1e-128: 412: 16.26
+	Hs
		313164 RAP2A_HUMAN (1-183): 7.32e-82: 241: 100.00		RPGF3_HUMAN (30-680): 3e-125: 403: 15.69
+	Hs
		313171 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		RPGF3_HUMAN (30-680): 3e-125: 403: 15.69
+	Hs
		486045 RAP2A_HUMAN (1-183): 7.32e-82: 241: 100.00		RPGF5_HUMAN (53-648): 2.74e-121: 382: 16.18
+	Hs
		919657 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		RPGF5_HUMAN (53-648): 2.74e-121: 382: 16.18
+	Hs
		919645 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		RGDSR_HUMAN (176-650): 3.89e-111: 351: 40.84
+	Hs
		486041 RAP2A_HUMAN (1-183): 7.32e-82: 241: 100.00		RPGF6_HUMAN (322-772): 3.38e-80: 286: 15.86
+	Hs
		897996 RAP2B_HUMAN (1-182): 2.01e-82: 243: 91.21		RPGF2_HUMAN (285-760): 2.42e-79: 284: 16.39
+	Hs
		919653 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		RPGF6_HUMAN (322-772): 3.38e-80: 286: 15.86
+	Hs
		919687 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		RPGF2_HUMAN (285-760): 2.42e-79: 284: 16.39
+	Hs
		897984 RAP2B_HUMAN (1-182): 2.01e-82: 243: 91.21		RPGF1_HUMAN (370-660): 1.16e-67: 247: 26.71
+	Hs
		919625 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		RPGF1_HUMAN (370-660): 1.16e-67: 247: 26.71
+	Hs
		486052 RAP2A_HUMAN (1-183): 7.32e-82: 241: 100.00		RGL1_HUMAN (58-252): 1.13e-47: 184: 46.00
+	Hs
		919681 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		RGL1_HUMAN (58-252): 1.13e-47: 184: 46.00