HitPredict

Interactor 1: RAP2A (P10114)
Ras-related protein Rap-2a (EC 3.6.5.2) (RbBP-30)
Gene: RAP2A

Interactor 2: RPGF5 (Q92565)
Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF) (Related to Epac) (Repac)
Gene: RAPGEF5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	10777494
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~RasGEF, Ras~RasGEF_N
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 183 Hs			1 580
+	Hs
		919657 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		RPGF5_HUMAN (1-580): 0: 597: 100.00
+	Hs
		486043 RAP2A_HUMAN (1-183): 7.32e-82: 241: 100.00		RPGF4_HUMAN (60-579): 4.62e-177: 529: 46.39
+	Hs
		919656 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		RPGF4_HUMAN (60-579): 4.62e-177: 529: 46.39
+	Hs
		313164 RAP2A_HUMAN (1-183): 7.32e-82: 241: 100.00		RPGF3_HUMAN (67-578): 5.04e-163: 490: 36.95
+	Hs
		313171 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		RPGF3_HUMAN (67-578): 5.04e-163: 490: 36.95
+	Hs
		313169 RAP1B_HUMAN (1-182): 4.24e-79: 234: 60.66		RPGF3_HUMAN (67-578): 5.04e-163: 490: 36.95
+	Dm
		51591 O96692_DROME (1-177): 8.99e-77: 229: 69.66		A1Z6P8_DROME (66-578): 1.06e-159: 484: 38.68
+	Hs
		897981 RAP2B_HUMAN (1-182): 2.01e-82: 243: 91.21		GNDS_HUMAN (70-578): 2.31e-131: 408: 15.37
+	Hs
		486024 RAP2A_HUMAN (1-183): 7.32e-82: 241: 100.00		GNDS_HUMAN (70-578): 2.31e-131: 408: 15.37
+	Hs
		919618 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		GNDS_HUMAN (70-578): 2.31e-131: 408: 15.37
+	Hs
		897883 RAP1B_HUMAN (1-182): 4.24e-79: 234: 60.66		GNDS_HUMAN (70-578): 2.31e-131: 408: 15.37
+	Hs
		897996 RAP2B_HUMAN (1-182): 2.01e-82: 243: 91.21		RPGF2_HUMAN (182-578): 7.88e-100: 333: 24.51
+	Hs
		486041 RAP2A_HUMAN (1-183): 7.32e-82: 241: 100.00		RPGF6_HUMAN (181-566): 5.18e-100: 334: 26.08
+	Hs
		919653 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		RPGF6_HUMAN (181-566): 5.18e-100: 334: 26.08
+	Hs
		919687 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		RPGF2_HUMAN (182-578): 7.88e-100: 333: 24.51
+	Hs
		897984 RAP2B_HUMAN (1-182): 2.01e-82: 243: 91.21		RPGF1_HUMAN (256-579): 3.76e-89: 299: 24.23
+	Hs
		919625 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		RPGF1_HUMAN (256-579): 3.76e-89: 299: 24.23
+	Dm
		442976 RAP1_DROME (1-165): 8.23e-81: 239: 64.24		Q9VMF3_DROME (214-563): 2.5e-88: 300: 30.28
+	Hs
		919645 RAP1A_HUMAN (1-182): 1.35e-81: 241: 61.75		RGDSR_HUMAN (116-578): 3.04e-91: 290: 12.17
+	Dm
		332231 O96692_DROME (1-177): 8.99e-77: 229: 69.66		Q9VMF3_DROME (214-563): 2.5e-88: 300: 30.28