HitPredict

Interactor 1: CCL3 (P10147)
C-C motif chemokine 3 (G0/G1 switch regulatory protein 19-1) (Macrophage inflammatory protein 1-alpha) (MIP-1-alpha) (PAT 464.1) (SIS-beta) (Small-inducible cytokine A3) (Tonsillar lymphocyte LD78 alpha protein) [Cleaved into: MIP-1-alpha(4-69) (LD78-alpha(4-69))]
Gene: CCL3

Interactor 2: CXCR5 (P32302)
C-X-C chemokine receptor type 5 (CXC-R5) (CXCR-5) (Burkitt lymphoma receptor 1) (Monocyte-derived receptor 15) (MDR-15) (CD antigen CD185)
Gene: CXCR5

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	11470772, 9312096
Identification Methods	biochemical
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0007186 - G protein-coupled receptor signaling pathway GO:0019722 - calcium-mediated signaling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 92 Hs			1 372
+	Hs
		526561 CCL4_HUMAN (1-91): 1.97e-33: 112: 57.61		CXCR5_HUMAN (1-372): 1.08e-91: 281: 100.00
+	Hs
		486237 CCL3_HUMAN (1-92): 2.25e-36: 119: 100.00		CCR3_HUMAN (21-367): 2.57e-74: 236: 28.45
+	Hs
		561732 CL3L1_HUMAN (1-92): 2.12e-35: 117: 94.62		CCR3_HUMAN (21-367): 2.57e-74: 236: 28.45
+	Hs
		830629 CCL13_HUMAN (1-92): 1.42e-33: 112: 38.71		CXCR3_HUMAN (14-350): 4.44e-75: 238: 39.76
+	Hs
		526564 CCL4_HUMAN (1-91): 1.97e-33: 112: 57.61		CCR3_HUMAN (21-367): 2.57e-74: 236: 28.45
+	Hs
		849619 CCL13_HUMAN (1-92): 1.42e-33: 112: 38.71		CCR3_HUMAN (21-367): 2.57e-74: 236: 28.45
+	Hs
		486230 CCL3_HUMAN (1-92): 2.25e-36: 119: 100.00		CCR1_HUMAN (33-367): 2.52e-71: 228: 27.68
+	Mm
		500591 CCL3_MOUSE (1-92): 6.45e-34: 113: 74.19		CCR3_MOUSE (29-367): 5.51e-73: 232: 27.35
+	Hs
		561728 CL3L1_HUMAN (1-92): 2.12e-35: 117: 94.62		CCR1_HUMAN (33-367): 2.52e-71: 228: 27.68
+	Hs
		783833 CCL13_HUMAN (1-92): 1.42e-33: 112: 38.71		CCR2_HUMAN (30-349): 1.29e-72: 232: 29.69
+	Hs
		526560 CCL4_HUMAN (1-91): 1.97e-33: 112: 57.61		CCR1_HUMAN (33-367): 2.52e-71: 228: 27.68
+	Hs
		486238 CCL3_HUMAN (1-92): 2.25e-36: 119: 100.00		CCR4_HUMAN (9-369): 2.41e-67: 218: 29.83
+	Hs
		486239 CCL3_HUMAN (1-92): 2.25e-36: 119: 100.00		CCR5_HUMAN (23-368): 2.9e-66: 215: 26.59
+	Hs
		561733 CL3L1_HUMAN (1-92): 2.12e-35: 117: 94.62		CCR5_HUMAN (23-368): 2.9e-66: 215: 26.59
+	Hs
		526565 CCL4_HUMAN (1-91): 1.97e-33: 112: 57.61		CCR5_HUMAN (23-368): 2.9e-66: 215: 26.59
+	Hs
		849654 CCL13_HUMAN (1-92): 1.42e-33: 112: 38.71		CCR5_HUMAN (23-368): 2.9e-66: 215: 26.59
+	Mm
		500590 CCL3_MOUSE (1-92): 6.45e-34: 113: 74.19		CCR1_MOUSE (22-367): 7.54e-65: 211: 28.82
+	Hs
		134354 CCL3_HUMAN (1-92): 2.25e-36: 119: 100.00		ACKR2_HUMAN (46-340): 4.16e-36: 137: 32.23
+	Hs
		134356 CCL4_HUMAN (1-91): 1.97e-33: 112: 57.61		ACKR2_HUMAN (46-340): 4.16e-36: 137: 32.23
+	Hs
		134400 CCL13_HUMAN (1-92): 1.42e-33: 112: 38.71		ACKR2_HUMAN (46-340): 4.16e-36: 137: 32.23