HitPredict

Interactor 1: CCL3 (P10147)
C-C motif chemokine 3 (G0/G1 switch regulatory protein 19-1) (Macrophage inflammatory protein 1-alpha) (MIP-1-alpha) (PAT 464.1) (SIS-beta) (Small-inducible cytokine A3) (Tonsillar lymphocyte LD78 alpha protein) [Cleaved into: MIP-1-alpha(4-69) (LD78-alpha(4-69))]
Gene: CCL3

Interactor 2: CCR5 (P51681)
C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5) (CHEMR13) (HIV-1 fusion coreceptor) (CD antigen CD195)
Gene: CCR5

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 1.00 0.933

The method score is based on:

Property Details
Experiments 11700073, 10477718, 9468473, 9334377, 9169459, 23765404
Identification Methods pull down, biochemical, experimental interaction detection, competition binding
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains 7tm_1~IL8
Common GO terms GO:0000165 - MAPK cascade
GO:0005737 - cytoplasm
GO:0006816 - calcium ion transport
GO:0006935 - chemotaxis
GO:0006954 - inflammatory response
and 6 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 92
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024