HitPredict

Interactor 1: CCL2 (P10148)
C-C motif chemokine 2 (Monocyte chemoattractant protein 1) (Monocyte chemotactic protein 1) (MCP-1) (Platelet-derived growth factor-inducible protein JE) (Small-inducible cytokine A2)
Gene: CCL2

Interactor 2: CCR2 (P51683)
C-C chemokine receptor type 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC receptor) (MCP-1 receptor) (CD antigen CD192)
Gene: CCR2

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.66 1.00 0.812

The method score is based on:

Property Details
Experiments 8631787, 8662823
Identification Methods pull down, competition binding
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains 7tm_1~IL8
Common GO terms GO:0001525 - angiogenesis
GO:0001666 - response to hypoxia
GO:0002548 - monocyte chemotaxis
GO:0006874 - intracellular calcium ion homeostasis
GO:0006954 - inflammatory response
and 16 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 148
Mm

1 373
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024