HitPredict

Interactor 1: ANDR (P10275)
Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
Gene: AR

Interactor 2: PTK6 (Q13882)
Protein-tyrosine kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK)
Gene: PTK6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005102 - signaling receptor binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 920 Hs			1 451
+	Hs
		487088 ANDR_HUMAN (1-920): 0: 966: 100.00		SRC_HUMAN (3-450): 0: 521: 43.30
+	Hs
		433225 ANDR_HUMAN (1-920): 0: 966: 100.00		YES_HUMAN (10-450): 0: 519: 42.86
+	Hs
		411564 ANDR_HUMAN (1-920): 0: 966: 100.00		LCK_HUMAN (3-449): 0: 517: 39.07
+	Hs
		442764 ANDR_HUMAN (1-920): 0: 966: 100.00		HCK_HUMAN (4-449): 8.95e-179: 511: 39.82
+	Hs
		337320 ANDR_HUMAN (1-920): 0: 966: 100.00		ABL1_HUMAN (1-449): 2.48e-170: 509: 35.17
+	Hs
		454790 ANDR_HUMAN (1-920): 0: 966: 100.00		FGR_HUMAN (10-450): 3.32e-177: 508: 42.41
+	Hs
		433537 ANDR_HUMAN (1-920): 0: 966: 100.00		LYN_HUMAN (3-449): 5.02e-177: 506: 38.19
+	Hs
		487203 ANDR_HUMAN (1-920): 0: 966: 100.00		ABL2_HUMAN (2-449): 1.97e-164: 495: 35.02
+	Hs
		487245 ANDR_HUMAN (1-920): 0: 966: 100.00		BLK_HUMAN (7-449): 2e-169: 487: 39.51
+	Hs
		487202 ANDR_HUMAN (1-920): 0: 966: 100.00		MATK_HUMAN (26-442): 7.22e-80: 258: 38.73
+	Hs
		368894 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		SRC_HUMAN (3-450): 0: 521: 43.30
+	Hs
		368834 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		YES_HUMAN (10-450): 0: 519: 42.86
+	Rn
		411266 ESR1_RAT (378-904): 2.19e-130: 406: 20.94		SRC_RAT (3-450): 0: 517: 43.08
+	Mm
		403414 ESR1_MOUSE (378-904): 2.5e-129: 403: 21.30		SRC_MOUSE (3-450): 0: 517: 43.08
+	Hs
		377007 GCR_HUMAN (444-920): 1.2e-117: 378: 40.85		FYN_HUMAN (10-450): 0: 521: 42.35
+	Hs
		377057 GCR_HUMAN (444-920): 1.2e-117: 378: 40.85		SRC_HUMAN (3-450): 0: 521: 43.30
+	Hs
		377006 GCR_HUMAN (444-920): 1.2e-117: 378: 40.85		LCK_HUMAN (3-449): 0: 517: 39.07
+	Hs
		522762 RXRA_HUMAN (392-902): 7.05e-120: 374: 19.84		SRC_HUMAN (3-450): 0: 521: 43.30
+	Hs
		523091 ESR2_HUMAN (435-912): 2.48e-116: 367: 21.51		SRC_HUMAN (3-450): 0: 521: 43.30
+	Hs
		433435 ESR2_HUMAN (435-912): 2.48e-116: 367: 21.51		YES_HUMAN (10-450): 0: 519: 42.86