HitPredict

Interactor 1: ANDR (P10275)
Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
Gene: AR

Interactor 2: MD12L (Q86YW9)
Mediator of RNA polymerase II transcription subunit 12-like protein (Mediator complex subunit 12-like protein) (Thyroid hormone receptor-associated-like protein) (Trinucleotide repeat-containing gene 11 protein-like)
Gene: MED12L

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	19762545
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008013 - beta-catenin binding GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 920 Hs			1 2145
+	Hs
		487651 ANDR_HUMAN (1-920): 0: 966: 100.00		MED12_HUMAN (1-2036): 0: 2238: 58.62
+	Hs
		370154 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		MED12_HUMAN (1-2036): 0: 2238: 58.62
+	Hs
		487803 ANDR_HUMAN (1-920): 0: 966: 100.00		CHD7_HUMAN (1582-2128): 8.44e-26: 119: 12.41
+	Hs
		487745 ANDR_HUMAN (1-920): 0: 966: 100.00		WDR33_HUMAN (1582-2011): 1.04e-17: 92.7: 9.79
+	Hs
		487832 ANDR_HUMAN (1-920): 0: 966: 100.00		ZMIZ1_HUMAN (1613-2060): 1.64e-15: 85.3: 11.89
+	Hs
		487375 ANDR_HUMAN (1-920): 0: 966: 100.00		EP300_HUMAN (1799-2145): 2.26e-11: 71.9: 11.05
+	Hs
		487433 ANDR_HUMAN (1-920): 0: 966: 100.00		NCOA6_HUMAN (1589-2051): 1.53e-09: 65.7: 9.29
+	Hs
		300519 ANDR_HUMAN (1-920): 0: 966: 100.00		NFAT5_HUMAN (1561-2133): 2.51e-09: 64.9: 11.07
+	Hs
		487596 ANDR_HUMAN (1-920): 0: 966: 100.00		KMT2C_HUMAN (1617-2119): 5.76e-09: 64.1: 9.24
+	Mm
		580491 ANDR_MOUSE (1-920): 0: 933: 84.30		NFAT5_MOUSE (1533-2141): 8.35e-11: 69.9: 11.52
+	Hs
		370607 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		CHD7_HUMAN (1582-2128): 8.44e-26: 119: 12.41
+	Hs
		368927 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		MUC1_HUMAN (1609-2061): 5.91e-20: 99: 6.97
+	Hs
		370092 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		ATX2L_HUMAN (1591-2142): 1.97e-13: 78.4: 10.93
+	Hs
		370286 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		ATX2_HUMAN (1782-2144): 2.21e-13: 78.4: 11.05
+	Hs
		369484 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		EP300_HUMAN (1799-2145): 2.26e-11: 71.9: 11.05
+	Hs
		369612 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		NCOA6_HUMAN (1589-2051): 1.53e-09: 65.7: 9.29
+	Hs
		370040 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		KMT2C_HUMAN (1617-2119): 5.76e-09: 64.1: 9.24
+	Mm
		70893 ESR1_MOUSE (378-904): 2.5e-129: 403: 21.30		EP300_MOUSE (1808-2143): 1.67e-11: 72.2: 10.95
+	Mm
		99856 ESR1_MOUSE (378-904): 2.5e-129: 403: 21.30		F6M2J9_MOUSE (1810-2144): 5.64e-09: 63.8: 11.05
+	Hs
		231019 GCR_HUMAN (444-920): 1.2e-117: 378: 40.85		L37A3_HUMAN (1609-2085): 1.01e-09: 66.4: 12.37