HitPredict

Interactor 1: RARA (P10276)
Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1)
Gene: RARA

Interactor 2: RXRB (P28702)
Retinoic acid receptor RXR-beta (Nuclear receptor subfamily 2 group B member 2) (Retinoid X receptor beta)
Gene: RXRB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.980

The method score is based on:

Property Details
Experiments 26871637, 29892012, 16189514, 28514442, 32296183, 15604093, 21988832, 31515488, 20211142, 25303530, unassigned1304
Identification Methods two hybrid, affinity chromatography technology, two hybrid array, pull down, anti tag coimmunoprecipitation, validated two hybrid, two hybrid prey pooling approach, two hybrid pooling approach
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Hormone_recep~Hormone_recep, Hormone_recep~zf-C4, zf-C4~zf-C4
Common GO terms GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0004879 - nuclear receptor activity
GO:0005634 - nucleus
and 14 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024