HitPredict

Interactor 1: RRAS (P10301)
Ras-related protein R-Ras (EC 3.6.5.-) (p23)
Gene: RRAS

Interactor 2: ARAF (P10398)
Serine/threonine-protein kinase A-Raf (EC 2.7.11.1) (Proto-oncogene A-Raf) (Proto-oncogene A-Raf-1) (Proto-oncogene Pks)
Gene: ARAF

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	12620389, 10848612
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1_1~Ras, RBD~Ras
Common GO terms	GO:0007265 - Ras protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 218 Hs			1 606
+	Hs
		488640 RRAS2_HUMAN (42-218): 1.8e-88: 260: 66.85		ARAF_HUMAN (1-606): 0: 579: 100.00
+	Hs
		373580 RRAS_HUMAN (1-218): 1.49e-97: 284: 100.00		RAF1_HUMAN (13-606): 0: 534: 60.53
+	Hs
		488650 RB11A_HUMAN (19-211): 4.72e-77: 232: 30.41		ARAF_HUMAN (1-606): 0: 579: 100.00
+	Hs
		373993 RRAS2_HUMAN (42-218): 1.8e-88: 260: 66.85		RAF1_HUMAN (13-606): 0: 534: 60.53
+	Hs
		542851 RAB1A_HUMAN (19-215): 1.94e-81: 243: 30.58		BRAF_HUMAN (3-604): 0: 546: 56.68
+	Hs
		374007 RAB1A_HUMAN (19-215): 1.94e-81: 243: 30.58		RAF1_HUMAN (13-606): 0: 534: 60.53
+	Hs
		374854 RAB1B_HUMAN (22-215): 1.41e-79: 238: 30.69		RAF1_HUMAN (13-606): 0: 534: 60.53
+	Hs
		374003 RB11A_HUMAN (19-211): 4.72e-77: 232: 30.41		RAF1_HUMAN (13-606): 0: 534: 60.53
+	Hs
		373973 RAB8A_HUMAN (22-218): 3.64e-76: 229: 27.89		RAF1_HUMAN (13-606): 0: 534: 60.53
+	Rn
		534421 RASH_RAT (42-217): 1.68e-56: 179: 53.41		ARAF_RAT (1-606): 0: 565: 95.22
+	Mm
		384063 RASH_MOUSE (42-217): 1.68e-56: 179: 53.41		ARAF_MOUSE (1-606): 0: 563: 94.88
+	Hs
		156090 RASM_HUMAN (21-199): 4.28e-56: 179: 56.11		BRAF_HUMAN (3-604): 0: 546: 56.68
+	Dm
		381631 RAS2_DROME (28-199): 1.88e-76: 229: 68.61		KRAF1_DROME (5-605): 2.05e-167: 496: 42.18
+	Hs
		156089 RASM_HUMAN (21-199): 4.28e-56: 179: 56.11		RAF1_HUMAN (13-606): 0: 534: 60.53
+	Rn
		507685 RASH_RAT (42-217): 1.68e-56: 179: 53.41		RAF1_RAT (13-606): 0: 529: 60.20
+	Hs
		488057 RRAS_HUMAN (1-218): 1.49e-97: 284: 100.00		SRC_HUMAN (282-568): 1.92e-104: 327: 30.24
+	Hs
		433312 RB11A_HUMAN (19-211): 4.72e-77: 232: 30.41		YES_HUMAN (289-568): 3.31e-104: 327: 31.34
+	Hs
		522882 RB11A_HUMAN (19-211): 4.72e-77: 232: 30.41		SRC_HUMAN (282-568): 1.92e-104: 327: 30.24
+	Hs
		523004 RB11B_HUMAN (19-211): 1.36e-76: 231: 31.44		SRC_HUMAN (282-568): 1.92e-104: 327: 30.24
+	Hs
		411957 RRAS_HUMAN (1-218): 1.49e-97: 284: 100.00		FYN_HUMAN (303-568): 1.51e-37: 148: 33.46