HitPredict

Interactor 1: RRAS (P10301)
Ras-related protein R-Ras (EC 3.6.5.-) (p23)
Gene: RRAS

Interactor 2: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.631

Property	Details
Experiments	10671570, 17474147
Identification Methods	pull down, affinity chromatography technology, two hybrid, peptide array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 218 Hs			1 377
+	Hs
		557649 RB11A_HUMAN (19-211): 4.72e-77: 232: 30.41		NCK1_HUMAN (1-377): 1.69e-98: 299: 100.00
+	Hs
		488062 RRAS_HUMAN (1-218): 1.49e-97: 284: 100.00		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		411957 RRAS_HUMAN (1-218): 1.49e-97: 284: 100.00		FYN_HUMAN (7-173): 7.47e-21: 96: 15.39
+	Hs
		488057 RRAS_HUMAN (1-218): 1.49e-97: 284: 100.00		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		488068 RRAS_HUMAN (1-218): 1.49e-97: 284: 100.00		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		655300 RRAS2_HUMAN (42-218): 1.8e-88: 260: 66.85		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		914091 RB11A_HUMAN (19-211): 4.72e-77: 232: 30.41		ITSN1_HUMAN (5-286): 1.55e-16: 83.6: 17.07
+	Mm
		1141162 RAB13_MOUSE (23-217): 1.63e-77: 233: 31.84		GRB2_MOUSE (1-61): 1.55e-16: 79.4: 29.03
+	Hs
		522882 RB11A_HUMAN (19-211): 4.72e-77: 232: 30.41		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		913994 RB11A_HUMAN (19-211): 4.72e-77: 232: 30.41		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		523004 RB11B_HUMAN (19-211): 1.36e-76: 231: 31.44		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		924599 RB11B_HUMAN (19-211): 1.36e-76: 231: 31.44		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		924749 RAB1C_HUMAN (22-215): 2.08e-76: 230: 31.68		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		924750 RAB8B_HUMAN (22-218): 3.37e-76: 230: 27.89		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		433312 RB11A_HUMAN (19-211): 4.72e-77: 232: 30.41		YES_HUMAN (112-218): 4.18e-11: 66.1: 19.27
+	Hs
		914272 RB11A_HUMAN (19-211): 4.72e-77: 232: 30.41		SH3K1_HUMAN (58-207): 2.14e-09: 61.3: 17.76
+	Mm
		643094 RASH_MOUSE (42-217): 1.68e-56: 179: 53.41		P85A_MOUSE (241-376): 1.59e-22: 101: 19.57
+	Hs
		349066 RASH_HUMAN (42-217): 1.68e-56: 179: 53.41		FYN_HUMAN (7-173): 7.47e-21: 96: 15.39
+	Rn
		589762 RASH_RAT (42-217): 1.68e-56: 179: 53.41		SRC_RAT (5-114): 1.36e-15: 80.1: 22.32
+	Hs
		349069 RASH_HUMAN (42-217): 1.68e-56: 179: 53.41		YES_HUMAN (112-218): 4.18e-11: 66.1: 19.27