HitPredict - High confidence protein-protein interactions

Interactor 1: BCL2 (P10415)
Apoptosis regulator Bcl-2
Gene: BCL2

Interactor 2: PSN1 (P49768)
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
Gene: PSEN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.620

Property	Details
Experiments	15905180, 10521466
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0006974 - DNA damage response and 13 others more... GO:0009791 - post-embryonic development GO:0010468 - regulation of gene expression GO:0016020 - membrane GO:0031965 - nuclear membrane GO:0032469 - endoplasmic reticulum calcium ion homeostasis GO:0032991 - protein-containing complex GO:0043065 - positive regulation of apoptotic process GO:0043066 - negative regulation of apoptotic process GO:0043524 - negative regulation of neuron apoptotic process GO:0048538 - thymus development GO:0051402 - neuron apoptotic process GO:0098609 - cell-cell adhesion GO:2001234 - negative regulation of apoptotic signaling pathway
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	239
Hs

1	467

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024