HitPredict

Interactor 1: BCL2 (P10415)
Apoptosis regulator Bcl-2
Gene: BCL2

Interactor 2: PP1B (P62140)
Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP-1B) (PPP1CD) (EC 3.1.3.16) (EC 3.1.3.53)
Gene: PPP1CB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	17274640
Identification Methods	affinity chromatography technology, antibody array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 239 Hs			1 327
+	Mm
		489480 BCL2_MOUSE (1-239): 2.11e-100: 293: 90.38		PP1A_MOUSE (1-326): 0: 576: 88.49
+	Mm
		489481 BCL2_MOUSE (1-239): 2.11e-100: 293: 90.38		PP1G_MOUSE (1-327): 0: 569: 86.89
+	Hs
		489393 BCL2_HUMAN (1-239): 1.24e-93: 276: 100.00		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Hs
		489378 BCL2_HUMAN (1-239): 1.24e-93: 276: 100.00		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Hs
		905852 B2CL1_HUMAN (11-239): 2.9e-77: 234: 42.68		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Hs
		737765 B2CL1_HUMAN (11-239): 2.9e-77: 234: 42.68		PP1G_HUMAN (1-327): 0: 569: 86.89
+	Mm
		926544 B2CL1_MOUSE (11-239): 2.79e-73: 224: 41.42		PP1G_MOUSE (1-327): 0: 569: 86.89
+	Hs
		489398 BCL2_HUMAN (1-239): 1.24e-93: 276: 100.00		PP2AA_HUMAN (8-303): 2.77e-176: 491: 45.79
+	Hs
		905851 BAX_HUMAN (34-231): 2.09e-51: 167: 24.27		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Hs
		906060 B2CL2_HUMAN (50-239): 5.97e-51: 166: 40.31		PP1A_HUMAN (1-326): 0: 576: 88.79
+	Mm
		926536 BAX_MOUSE (34-231): 2.52e-49: 161: 21.36		PP1G_MOUSE (1-327): 0: 569: 86.89