HitPredict - High confidence protein-protein interactions

Interactor 1: BCL2 (P10415)
Apoptosis regulator Bcl-2
Gene: BCL2

Interactor 2: BAX (Q07812)
Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4)
Gene: BAX

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.990

Property	Details
Experiments	9111042, 16642033, 17097560, 21199865, 29749471, 8358790, 10620799, 21778226, 23479509, 15231068, 14980220, 15899854, 24141421, 32064756, 33961781, 22262057, 10716992, 18981409, 17525161, 26004684 and 5 others more... 21671007, 17289999, 9463381, 9388232, 17525735
Identification Methods	pull down, affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, enzyme linked immunosorbent assay
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Bcl-2~Bcl-2, BH4~Bcl-2
Common GO terms	GO:0001541 - ovarian follicle development GO:0001782 - B cell homeostasis GO:0001783 - B cell apoptotic process GO:0001836 - release of cytochrome c from mitochondria GO:0005634 - nucleus and 30 others more... GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol GO:0006808 - regulation of nitrogen utilization GO:0006915 - apoptotic process GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors GO:0008630 - intrinsic apoptotic signaling pathway in response to DNA damage GO:0009636 - response to toxic substance GO:0010332 - response to gamma radiation GO:0015267 - channel activity GO:0016020 - membrane GO:0032469 - endoplasmic reticulum calcium ion homeostasis GO:0042803 - protein homodimerization activity GO:0043065 - positive regulation of apoptotic process GO:0043524 - negative regulation of neuron apoptotic process GO:0046666 - retinal cell programmed cell death GO:0046930 - pore complex GO:0046982 - protein heterodimerization activity GO:0048873 - homeostasis of number of cells within a tissue GO:0051434 - BH3 domain binding GO:0051881 - regulation of mitochondrial membrane potential GO:0060402 - calcium ion transport into cytosol GO:0070059 - intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0097049 - motor neuron apoptotic process GO:0097192 - extrinsic apoptotic signaling pathway in absence of ligand GO:1904019 - epithelial cell apoptotic process GO:2001234 - negative regulation of apoptotic signaling pathway
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1	239
Hs

1	192

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024