HitPredict

Interactor 1: BCL2 (P10415)
Apoptosis regulator Bcl-2
Gene: BCL2

Interactor 2: APR (Q13794)
Phorbol-12-myristate-13-acetate-induced protein 1 (PMA-induced protein 1) (Immediate-early-response protein APR) (Protein Noxa)
Gene: PMAIP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

The method score is based on:

Property	Details
Experiments	15694340, 10807576, 21454712
Identification Methods	unspecified method, affinity chromatography technology, surface plasmon resonance, pull down, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Bcl-2~PMAIP1
Common GO terms	GO:0001836 - release of cytochrome c from mitochondria GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0005741 - mitochondrial outer membrane GO:0005829 - cytosol and 9 others more... GO:0006915 - apoptotic process GO:0006974 - DNA damage response GO:0042149 - cellular response to glucose starvation GO:0043029 - T cell homeostasis GO:0043065 - positive regulation of apoptotic process GO:0046902 - regulation of mitochondrial membrane permeability GO:0051607 - defense response to virus GO:0071456 - cellular response to hypoxia GO:0072593 - reactive oxygen species metabolic process
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	239
Hs

1	54

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024