HitPredict

Interactor 1: BCL2 (P10415)
Apoptosis regulator Bcl-2
Gene: BCL2

Interactor 2: ITPR1 (Q14643)
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Inositol 1,4,5 trisphosphate receptor) (Inositol 1,4,5-trisphosphate receptor type 1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor)
Gene: ITPR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.634

The method score is based on:

Property	Details
Experiments	19706527, 15613488
Identification Methods	pull down, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0009791 - post-embryonic development GO:0016020 - membrane GO:0032469 - endoplasmic reticulum calcium ion homeostasis and 1 others more... GO:0070059 - intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1	239
Hs

1	2758

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024