HitPredict

Interactor 1: BCL2 (P10415)
Apoptosis regulator Bcl-2
Gene: BCL2

Interactor 2: BAK (Q16611)
Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2-like protein 7) (Bcl2-L-7)
Gene: BAK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.86 1.00 0.930

The method score is based on:

Property Details
Experiments 20836993, 14980220, 32064756, 11728179, 26004684, 9463381
Identification Methods affinity chromatography technology, unspecified method, fluorescence polarization spectroscopy, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Bcl-2~Bcl-2, BH4~Bcl-2
Common GO terms GO:0001782 - B cell homeostasis
GO:0001783 - B cell apoptotic process
GO:0001836 - release of cytochrome c from mitochondria
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
and 18 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 239
Hs

1 211
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024