HitPredict

Interactor 1: BCL2 (P10415)
Apoptosis regulator Bcl-2
Gene: BCL2

Interactor 2: BMF (Q96LC9)
Bcl-2-modifying factor
Gene: BMF

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.814

Property	Details
Experiments	11546872, 16697956, 17289999
Identification Methods	affinity chromatography technology, unspecified method, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	BMF~Bcl-2
Common GO terms	GO:0005741 - mitochondrial outer membrane GO:0005829 - cytosol GO:0010507 - negative regulation of autophagy GO:0043065 - positive regulation of apoptotic process
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 239 Hs			1 184
+	Hs
		992114 B2CL1_HUMAN (11-239): 2.9e-77: 234: 42.68		BMF_HUMAN (1-184): 1.16e-124: 350: 100.00
+	Hs
		1271716 B2CL2_HUMAN (50-239): 5.97e-51: 166: 40.31		BMF_HUMAN (1-184): 1.16e-124: 350: 100.00
+	Hs
		1083079 B2LA1_HUMAN (84-235): 2.97e-44: 148: 23.42		BMF_HUMAN (1-184): 1.16e-124: 350: 100.00
+	Hs
		992190 MCL1_HUMAN (68-232): 6.24e-39: 139: 22.89		BMF_HUMAN (1-184): 1.16e-124: 350: 100.00
+	Mm
		991238 B2LA1_MOUSE (84-219): 1.26e-43: 146: 26.06		BMF_MOUSE (1-183): 2.52e-121: 341: 87.50
+	Mm
		956156 MCL1_MOUSE (68-232): 2.25e-39: 140: 22.89		BMF_MOUSE (1-183): 2.52e-121: 341: 87.50
+	Hs
		1297096 B2L10_HUMAN (82-232): 6.74e-33: 120: 18.71		BMF_HUMAN (1-184): 1.16e-124: 350: 100.00
+	Hs
		3079 A0A0S2Z3D2_HUMAN (11-133): 2.67e-29: 109: 33.33		BMF_HUMAN (1-184): 1.16e-124: 350: 100.00