HitPredict

Interactor 1: BCL2 (P10415)
Apoptosis regulator Bcl-2
Gene: BCL2

Interactor 2: BBC3B (Q96PG8)
Bcl-2-binding component 3, isoforms 3/4 (JFY-1) (p53 up-regulated modulator of apoptosis)
Gene: BBC3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.683

Property	Details
Experiments	15694340, 11463392, 16697956, 33961781
Identification Methods	affinity chromatography technology, unspecified method, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001836 - release of cytochrome c from mitochondria GO:0005739 - mitochondrion GO:0006915 - apoptotic process GO:0070059 - intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 239 Hs			1 261
+	Hs
		992116 B2CL1_HUMAN (11-239): 2.9e-77: 234: 42.68		BBC3B_HUMAN (1-261): 2.85e-107: 312: 100.00
+	Hs
		992035 BAX_HUMAN (34-231): 2.09e-51: 167: 24.27		BBC3B_HUMAN (1-261): 2.85e-107: 312: 100.00
+	Hs
		1271717 B2CL2_HUMAN (50-239): 5.97e-51: 166: 40.31		BBC3B_HUMAN (1-261): 2.85e-107: 312: 100.00
+	Hs
		1083080 B2LA1_HUMAN (84-235): 2.97e-44: 148: 23.42		BBC3B_HUMAN (1-261): 2.85e-107: 312: 100.00
+	Hs
		992191 MCL1_HUMAN (68-232): 6.24e-39: 139: 22.89		BBC3B_HUMAN (1-261): 2.85e-107: 312: 100.00