Interactor 1: ODP2 (P10515)
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)
Gene: DLAT

Interactor 2: ODPB (P11177)
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1)
Gene: PDHB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.86 1.00 0.929

The method score is based on:

Property Details
Experiments 26186194, 28514442, 33961781, 14638692, 18206651
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation, molecular sieving, surface plasmon resonance
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains E3_binding~Transketolase_C
Common GO terms GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006006 - glucose metabolic process
GO:0006086 - acetyl-CoA biosynthetic process from pyruvate
GO:0006099 - tricarboxylic acid cycle
and 1 others

more...

Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 647
Hs

1 359
+ Hs
+ Hs
+ Mm
+ Ce
+ Sc
+ Sc
+ Ss
+ Hs

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Last updated: 15 Jul 2024