HitPredict

Interactor 1: ODP2 (P10515)
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)
Gene: DLAT

Interactor 2: PDK1 (Q15118)
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)
Gene: PDK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	29568061, 11978179
Identification Methods	proximity labelling technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix GO:0006006 - glucose metabolic process
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 647 Hs			1 436
+	Hs
		489748 ODP2_HUMAN (1-647): 0: 672: 100.00		PDK2_HUMAN (37-436): 0: 604: 69.25
+	Hs
		489749 ODP2_HUMAN (1-647): 0: 672: 100.00		PDK3_HUMAN (42-435): 0: 589: 68.61
+	Mm
		222980 ODP2_MOUSE (1-647): 0: 655: 85.47		BCKD_MOUSE (1-398): 3.29e-160: 459: 28.27
+	Hs
		126245 ODPX_HUMAN (23-189): 1.77e-29: 124: 31.14		PDK1_HUMAN (1-436): 0: 674: 100.00
+	Hs
		739124 ODO2_HUMAN (16-163): 1.19e-25: 112: 20.95		PDK1_HUMAN (1-436): 0: 674: 100.00
+	Hs
		126246 ODPX_HUMAN (23-189): 1.77e-29: 124: 31.14		PDK2_HUMAN (37-436): 0: 604: 69.25
+	Hs
		126247 ODPX_HUMAN (23-189): 1.77e-29: 124: 31.14		PDK3_HUMAN (42-435): 0: 589: 68.61
+	Hs
		81542 ODPX_HUMAN (23-189): 1.77e-29: 124: 31.14		B7Z207_HUMAN (156-436): 1.39e-167: 473: 100.00
+	Mm
		222971 ODB2_MOUSE (70-279): 7.81e-12: 69.9: 15.17		BCKD_MOUSE (1-398): 3.29e-160: 459: 28.27