HitPredict

Interactor 1: ODP2 (P10515)
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)
Gene: DLAT

Interactor 2: SIR4 (Q9Y6E7)
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial (EC 2.3.1.-) (NAD-dependent ADP-ribosyltransferase sirtuin-4) (EC 2.4.2.-) (NAD-dependent protein biotinylase sirtuin-4) (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-4) (EC 2.3.1.286) (Regulatory protein SIR2 homolog 4) (SIR2-like protein 4)
Gene: SIRT4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	25525879
Identification Methods	anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, lipoprotein cleavage assay
Interaction Type	physical association, association, lipoprotein cleavage reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 647 Hs			1 314
+	Hs
		489826 ODP2_HUMAN (1-647): 0: 672: 100.00		SIR3_HUMAN (39-312): 8.61e-87: 267: 27.34
+	Hs
		489825 ODP2_HUMAN (1-647): 0: 672: 100.00		SIR7_HUMAN (29-311): 9.49e-74: 234: 26.46
+	Hs
		126290 ODPX_HUMAN (23-189): 1.77e-29: 124: 31.14		SIR4_HUMAN (1-314): 1.07e-143: 409: 100.00
+	Hs
		739369 ODO2_HUMAN (16-163): 1.19e-25: 112: 20.95		SIR4_HUMAN (1-314): 1.07e-143: 409: 100.00
+	Hs
		506090 ODB2_HUMAN (84-213): 9.1e-13: 72.9: 17.65		SIR4_HUMAN (1-314): 1.07e-143: 409: 100.00