HitPredict

Interactor 1: ARRS (P10523)
S-arrestin (48 kDa protein) (Retinal S-antigen) (S-AG) (Rod photoreceptor arrestin)
Gene: SAG

Interactor 2: ARRB2 (P32121)
Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3)
Gene: ARRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	17620599
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Arrestin_C~Arrestin_C, Arrestin_C~Arrestin_N, Arrestin_N~Arrestin_N
Common GO terms	GO:0001664 - G protein-coupled receptor binding GO:0002031 - G protein-coupled receptor internalization GO:0005829 - cytosol
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 405 Hs			1 409
+	Hs
		685845 ARRB1_HUMAN (13-399): 0: 626: 56.51		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Mm
		1207384 ARRB1_MOUSE (13-390): 0: 615: 57.04		ARRB2_MOUSE (1-409): 0: 682: 96.34
+	Hs
		489849 ARRS_HUMAN (1-405): 0: 633: 100.00		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Hs
		827122 ARRB1_HUMAN (13-399): 0: 626: 56.51		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Hs
		685806 ARRB2_HUMAN (11-394): 0: 593: 52.08		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Rn
		663949 ARRB2_RAT (11-394): 0: 587: 51.46		ARRB2_RAT (1-409): 0: 682: 95.85
+	Hs
		489847 ARRS_HUMAN (1-405): 0: 633: 100.00		ARRS_HUMAN (4-407): 0: 541: 51.91
+	Bt
		436867 ARRS_BOVIN (6-401): 0: 617: 85.68		ARRS_BOVIN (5-405): 0: 553: 51.46
+	Hs
		736269 ARRB1_HUMAN (13-399): 0: 626: 56.51		ARRC_HUMAN (7-393): 0: 534: 53.79
+	Mm
		593478 ARRS_MOUSE (1-401): 0: 612: 88.28		ARRS_MOUSE (6-407): 0: 534: 51.33
+	Hs
		685817 ARRB2_HUMAN (11-394): 0: 593: 52.08		ARRC_HUMAN (7-393): 0: 534: 53.79
+	Hs
		827233 ARRB1_HUMAN (13-399): 0: 626: 56.51		Q7Z3R3_HUMAN (179-351): 1.66e-86: 263: 57.54