HitPredict

Interactor 1: NR2F6 (P10588)
Nuclear receptor subfamily 2 group F member 6 (V-erbA-related protein 2) (EAR-2)
Gene: NR2F6

Interactor 2: COT2 (P24468)
COUP transcription factor 2 (COUP-TF2) (Apolipoprotein A-I regulatory protein 1) (ARP-1) (COUP transcription factor II) (COUP-TF II) (Nuclear receptor subfamily 2 group F member 2)
Gene: NR2F2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.81 1.00 0.903

The method score is based on:

Property Details
Experiments 28514442, 10318855, 33961781, 15604093
Identification Methods affinity chromatography technology, two hybrid, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Hormone_recep~Hormone_recep, Hormone_recep~zf-C4, zf-C4~zf-C4
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0004879 - nuclear receptor activity
GO:0005634 - nucleus
and 4 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024