HitPredict

Interactor 1: COT1 (P10589)
COUP transcription factor 1 (COUP-TF1) (COUP transcription factor I) (COUP-TF I) (Nuclear receptor subfamily 2 group F member 1) (V-erbA-related protein 3) (EAR-3)
Gene: NR2F1

Interactor 2: FOXG1 (P55316)
Forkhead box protein G1 (Brain factor 1) (BF-1) (BF1) (Brain factor 2) (BF-2) (BF2) (hBF-2) (Forkhead box protein G1A) (Forkhead box protein G1B) (Forkhead box protein G1C) (Forkhead-related protein FKHL1) (HFK1) (Forkhead-related protein FKHL2) (HFK2) (Forkhead-related protein FKHL3) (HFK3)
Gene: FOXG1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	25609649
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:1990837 - sequence-specific double-stranded DNA binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 423 Hs			1 489
+	Hs
		490105 COT1_HUMAN (1-423): 1.76e-155: 447: 100.00		FOXP4_HUMAN (55-340): 6.09e-54: 194: 27.59
+	Hs
		490092 COT1_HUMAN (1-423): 1.76e-155: 447: 100.00		FOXA3_HUMAN (80-293): 2.39e-51: 179: 35.35
+	Hs
		490113 COT1_HUMAN (1-423): 1.76e-155: 447: 100.00		FOXC2_HUMAN (115-470): 1.92e-49: 178: 27.94
+	Hs
		490099 COT1_HUMAN (1-423): 1.76e-155: 447: 100.00		FOXL1_HUMAN (155-288): 2.31e-48: 171: 47.02
+	Hs
		208887 COT1_HUMAN (1-423): 1.76e-155: 447: 100.00		FOXS1_HUMAN (165-416): 5.89e-46: 164: 33.46
+	Hs
		622804 COT2_HUMAN (1-421): 1.77e-138: 404: 84.27		FOXP4_HUMAN (55-340): 6.09e-54: 194: 27.59
+	Hs
		622779 COT2_HUMAN (1-421): 1.77e-138: 404: 84.27		FOXA1_HUMAN (80-448): 8.86e-50: 178: 22.84
+	Hs
		782521 HNF4A_HUMAN (27-414): 8.3e-117: 350: 31.96		FOXK2_HUMAN (67-456): 6.09e-58: 204: 24.64
+	Hs
		782530 HNF4A_HUMAN (27-414): 8.3e-117: 350: 31.96		FOXO1_HUMAN (60-474): 2.23e-51: 186: 22.90
+	Hs
		487956 RARA_HUMAN (3-417): 3.02e-115: 346: 25.41		FOXO1_HUMAN (60-474): 2.23e-51: 186: 22.90
+	Hs
		369425 ESR1_HUMAN (7-423): 1.55e-104: 323: 23.25		FOXK2_HUMAN (67-456): 6.09e-58: 204: 24.64
+	Hs
		487931 RARA_HUMAN (3-417): 3.02e-115: 346: 25.41		FOXA1_HUMAN (80-448): 8.86e-50: 178: 22.84
+	Hs
		782535 HNF4A_HUMAN (27-414): 8.3e-117: 350: 31.96		FOXC1_HUMAN (142-271): 2.43e-47: 173: 50.77
+	Hs
		369487 ESR1_HUMAN (7-423): 1.55e-104: 323: 23.25		FOXO1_HUMAN (60-474): 2.23e-51: 186: 22.90
+	Hs
		369403 ESR1_HUMAN (7-423): 1.55e-104: 323: 23.25		FOXK1_HUMAN (71-309): 9.43e-50: 183: 31.15
+	Hs
		206786 ESR1_HUMAN (7-423): 1.55e-104: 323: 23.25		FOXO3_HUMAN (59-468): 1.2e-48: 179: 20.70
+	Hs
		369258 ESR1_HUMAN (7-423): 1.55e-104: 323: 23.25		FOXA1_HUMAN (80-448): 8.86e-50: 178: 22.84
+	Hs
		206833 NR1H3_HUMAN (4-406): 8.12e-104: 317: 25.52		FOXO3_HUMAN (59-468): 1.2e-48: 179: 20.70
+	Hs
		377289 GCR_HUMAN (3-422): 2.13e-102: 322: 21.97		FOXL1_HUMAN (155-288): 2.31e-48: 171: 47.02
+	Mm
		291643 ESR1_MOUSE (10-411): 4.59e-101: 314: 22.99		FOXL2_MOUSE (134-324): 2.51e-47: 169: 37.70